Replaces Prod. #: ALX-270-259
Cell permeable, potent and selective p38 MAP kinase inhibitor (IC50=30 nM). Inhibits p38α and ß, but not γ and δ isoforms. Does not inhibit ERK2 or other members of the MAP kinase family or their upstream activators. A useful tool for dissecting the role of p38 in signaling pathways. Induces apoptosis.
Product Details
Alternative Name: | FHPI, 4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole |
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Formula: | C20H14FN3O |
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MW: | 331.3 |
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CAS: | 152121-30-7 |
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Purity: | ≥98% (TLC) |
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Appearance: | Pale yellow solid. |
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Solubility: | Soluble in methanol, DMSO or acetone; slightly soluble in ethyl acetate. |
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Shipping: | Ambient |
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Long Term Storage: | -20°C |
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Use/Stability: | Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C. |
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Handling: | Protect from light. |
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Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Shiga toxin sub-type 2a increases the efficiency of Escherichia coli O157 transmission between animals and restricts epithelial regeneration in bovine enteroids: S.F. Fitzgerald, et al.; PLoS Pathog.
15, e1008003 (2019),
Abstract;
Full Text
Development of in vitro enteroids derived from bovine small intestinal crypts: C.A. Hamilton, et al.; Vet. Res.
49, 54 (2018),
Abstract;
Full Text
Eupafolin nanoparticles protect HaCaT keratinocytes from particulate matter-induced inflammation and oxidative stress: Z.C. Lin, et al.; Int. J. Nanomedicine
11, 3907 (2016),
Application(s): Cell treatment to see effect on PM-induced phosphorylation,
Abstract;
Full Text
SOCS1 suppresses IL-1β-induced C/EBPβ expression via transcriptional regulation in human chondrocytes: Y.J. Ha, et al.; Exp. Mol. Med.
48, e241 (2016),
Application(s): Transcriptional regulation and CREB phosphorylation activity,
Abstract;
Full Text
Extract from Acanthopanax senticosus prevents LPS-induced monocytic cell adhesion via suppression of LFA-1 and Mac-1: H.J. Kim, et al.; Can. J. Physiol. Pharmacol.
92, 278 (2014),
Application(s): PCR experiments revealed that AS extract inhibited LPS-induced expression of genes encoding lymphocyte function-associated antigen-1 (LFA-1) and macrophage-1 antigen (Mac-1) in THP-1 cells,
Abstract;
PTX3 Stimulates Osteoclastogenesis by Increasing Osteoblast RANKL Production: E.J. Lee, et al.; J. Cell. Physiol.
229, 1744 (2014),
Application(s): Knock-down of endogenous PTX3 with small-interfering RNA did not change the osteogenic potential of pOBs but suppressed their production of RANKL and reduced osteoclastogenesis,
Abstract;
The prostaglandin E2 receptor EP4 is integral to a positive feedback loop for prostaglandin E2 production in human macrophages infected with Mycobacterium tuberculosis: T. Nishimura, et al.; FASEB J.
27, 3827 (2013),
Application(s): PGE2 production induced by pathogen recognition receptors/p38 MAPK signaling is up-regulated by EP4-triggered signaling to maintain an effective PGE2 concentration,
Abstract;
Nitric oxide induces cell death in canine cruciate ligament cells by activation of tyrosine kinase and reactive oxygen species: S. Forterre, et al.; BMC Vet. Res.
8, 40 (2012),
Application(s): WB, Assays,
Abstract;
Full Text
Systems kinomics demonstrates Congo Basin monkeypox virus infection selectively modulates host cell signaling responses as compared to West African monkeypox virus: J. Kindrachuk, et al.; Mol. Cell. Proteomics
11, M111.015701 (2012),
Application(s): ELISA,
Abstract;
Full Text
Epithelial cell senescence impairs repair process and exacerbates inflammation after airway injury: F. Zhou, et al.; Respir. Res.
12, 78 (2011),
Application(s): ELISA, WB, IHC, IF,
Abstract;
Full Text
Human NDR kinases control G(1)/S cell cycle transition by directly regulating p21 stability: H. Cornils, et al.; Mol. Cell. Biol.
31, 1382 (2011),
Application(s): IP, WB, Assays,
Abstract;
Full Text
Roles for TGF-beta and programmed cell death 1 ligand 1 in regulatory T cell expansion and diabetes suppression by zymosan in nonobese diabetic mice: O.T. Burton, et al.; J. Immunol.
185, 2754 (2010),
Application(s): Flow, PCR,
Abstract;
Full Text
One-way cross-talk between p38(MAPK) and p42/44(MAPK). Inhibition of p38(MAPK) induces low density lipoprotein receptor expression through activation of the p42/44(MAPK) cascade: R.P. Singh, et al.; J. Biol. Chem.
274, 19593 (1999),
Abstract;
A single amino acid substitution makes ERK2 susceptible to pyridinyl imidazole inhibitors of p38 MAP kinase: T. Fox, et al.; Protein Sci.
7, 2249 (1998),
Abstract;
Induction of apoptosis by SB202190 through inhibition of p38beta mitogen-activated protein kinase: S. Nemoto, et al.; J. Biol. Chem.
273, 16415 (1998),
Abstract;
The cellular response to oxidative stress: influences of mitogen-activated protein kinase signalling pathways on cell survival: X. Wang, et al.; Biochem. J.
333, 291 (1998),
Abstract;
Regulation of stress-induced cytokine production by pyridinylimidazoles; inhibition of CSBP kinase: T.F. Gallagher, et al.; Bioorg. Med. Chem.
5, 49 (1997),
Abstract;
Characterization of the structure and function of a new mitogen-activated protein kinase (p38beta): Y. Jiang, et al.; J. Biol. Chem.
271, 17920 (1996),
Abstract;
The primary structure of p38 gamma: a new member of p38 group of MAP kinases: Z. Li, et al.; Biochem. Biophys. Res. Commun.
228, 334 (1996),
Abstract;
SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1: A. Cuenda, et al.; FEBS Lett.
364, 229 (1995),
Abstract;
A protein kinase involved in the regulation of inflammatory cytokine biosynthesis: J.C. Lee, et al.; Nature
372, 739 (1994),
Abstract;
Inside-out chicken enteroids with leukocyte component as a model to study host-pathogen interactions: T.J. Nash, et al.; Commun. Biol.
4, 377 ( 2021),
Abstract;