Replaces Prod. #: ALX-270-259
Cell permeable, potent and selective p38 MAP kinase inhibitor (IC50=30 nM). Inhibits p38α and ß, but not γ and δ isoforms. Does not inhibit ERK2 or other members of the MAP kinase family or their upstream activators. A useful tool for dissecting the role of p38 in signaling pathways. Induces apoptosis.
Product Details
| Alternative Name: | FHPI, 4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole |
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| Formula: | C20H14FN3O |
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| MW: | 331.3 |
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| CAS: | 152121-30-7 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | Pale yellow solid. |
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| Solubility: | Soluble in methanol, DMSO or acetone; slightly soluble in ethyl acetate. |
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| Shipping: | Ambient |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C. |
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| Handling: | Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
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Eupafolin nanoparticles protect HaCaT keratinocytes from particulate matter-induced inflammation and oxidative stress: Z.C. Lin, et al.; Int. J. Nanomedicine
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SOCS1 suppresses IL-1β-induced C/EBPβ expression via transcriptional regulation in human chondrocytes: Y.J. Ha, et al.; Exp. Mol. Med.
48, e241 (2016),
Application(s): Transcriptional regulation and CREB phosphorylation activity,
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Extract from Acanthopanax senticosus prevents LPS-induced monocytic cell adhesion via suppression of LFA-1 and Mac-1: H.J. Kim, et al.; Can. J. Physiol. Pharmacol.
92, 278 (2014),
Application(s): PCR experiments revealed that AS extract inhibited LPS-induced expression of genes encoding lymphocyte function-associated antigen-1 (LFA-1) and macrophage-1 antigen (Mac-1) in THP-1 cells,
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PTX3 Stimulates Osteoclastogenesis by Increasing Osteoblast RANKL Production: E.J. Lee, et al.; J. Cell. Physiol.
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Application(s): Knock-down of endogenous PTX3 with small-interfering RNA did not change the osteogenic potential of pOBs but suppressed their production of RANKL and reduced osteoclastogenesis,
Abstract;
The prostaglandin E2 receptor EP4 is integral to a positive feedback loop for prostaglandin E2 production in human macrophages infected with Mycobacterium tuberculosis: T. Nishimura, et al.; FASEB J.
27, 3827 (2013),
Application(s): PGE2 production induced by pathogen recognition receptors/p38 MAPK signaling is up-regulated by EP4-triggered signaling to maintain an effective PGE2 concentration,
Abstract;
Nitric oxide induces cell death in canine cruciate ligament cells by activation of tyrosine kinase and reactive oxygen species: S. Forterre, et al.; BMC Vet. Res.
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Full Text
Systems kinomics demonstrates Congo Basin monkeypox virus infection selectively modulates host cell signaling responses as compared to West African monkeypox virus: J. Kindrachuk, et al.; Mol. Cell. Proteomics
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Epithelial cell senescence impairs repair process and exacerbates inflammation after airway injury: F. Zhou, et al.; Respir. Res.
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Human NDR kinases control G(1)/S cell cycle transition by directly regulating p21 stability: H. Cornils, et al.; Mol. Cell. Biol.
31, 1382 (2011),
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Roles for TGF-beta and programmed cell death 1 ligand 1 in regulatory T cell expansion and diabetes suppression by zymosan in nonobese diabetic mice: O.T. Burton, et al.; J. Immunol.
185, 2754 (2010),
Application(s): Flow, PCR,
Abstract;
Full Text
One-way cross-talk between p38(MAPK) and p42/44(MAPK). Inhibition of p38(MAPK) induces low density lipoprotein receptor expression through activation of the p42/44(MAPK) cascade: R.P. Singh, et al.; J. Biol. Chem.
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A single amino acid substitution makes ERK2 susceptible to pyridinyl imidazole inhibitors of p38 MAP kinase: T. Fox, et al.; Protein Sci.
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The cellular response to oxidative stress: influences of mitogen-activated protein kinase signalling pathways on cell survival: X. Wang, et al.; Biochem. J.
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Regulation of stress-induced cytokine production by pyridinylimidazoles; inhibition of CSBP kinase: T.F. Gallagher, et al.; Bioorg. Med. Chem.
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Characterization of the structure and function of a new mitogen-activated protein kinase (p38beta): Y. Jiang, et al.; J. Biol. Chem.
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Abstract;
The primary structure of p38 gamma: a new member of p38 group of MAP kinases: Z. Li, et al.; Biochem. Biophys. Res. Commun.
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SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1: A. Cuenda, et al.; FEBS Lett.
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A protein kinase involved in the regulation of inflammatory cytokine biosynthesis: J.C. Lee, et al.; Nature
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Inside-out chicken enteroids with leukocyte component as a model to study host-pathogen interactions: T.J. Nash, et al.; Commun. Biol.
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