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United States 

BAY 11-7082

NF-κB inhibitor
BML-EI278-0010 10 mg 113.00 USD
BML-EI278-0050 50 mg 462.00 USD
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Replaces Prod. #: ALX-270-219

Inhibitor of cytokine induced IκBα phosphorylation resulting thereby in a decreased expression of NF-κB and adhesion molecules. Potential anti-inflammatory agent.

Product Details

Alternative Name:(E)-3-[(4-methylphenylsulfonyl]-2-propenenitrile
Purity:≥99% (HPLC)
Appearance:White to off-white solid.
Solubility:Soluble in DMSO, 100% ethanol, methanol or methylene dichloride; insoluble in water.
Shipping:Ambient Temperature
Long Term Storage:Ambient
Handling:Protect from light. Keep under inert gas.
Regulatory Status:RUO - Research Use Only
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Product Literature References

TNF-α and NF-κB signaling play a critical role in cigarette smoke-induced epithelial-mesenchymal transition of retinal pigment epithelial cells in proliferative vitreoretinopathy: V. Wang, et al.; PLoS One 17, e0271950 (2022), Abstract;
Activation of NLRP3 by uropathogenic Escherichia coli is associated with IL-1β release and regulation of antimicrobial properties in human neutrophils: I. Demirel, et al.; Sci. Rep. 10, 21837 (2020), Abstract; Full Text
Luteolin Attenuates IL-1 β-Induced THP-1 Adhesion to ARPE-19 Cells via Suppression of NF- κ B and MAPK Pathways: W. Huang, et al.; Mediators Inflamm. 2020, 9421340 (2020), Abstract; Full Text
Effect of Glutamate on Brain Iron Metabolism and the Regulation Mechanism: P. Yu, et al.; J. Drug Metab. Toxicol. 6, 190 (2015), Application(s): Cell culture , Full Text
Lipopolysaccharide induction of REDD1 is mediated by two distinct CREB-dependent mechanisms in macrophages: D.K. Lee, et al.; FEBS Lett. 589, 2859 (2015), Application(s): Cell Culture, Abstract;
Sterile-filtered saliva is a strong inducer of IL-6 and IL-8 in oral fibroblasts: B. Cvikl, et al.; Clin. Oral. Investig. 19, 385 (2015), Application(s): Treatment of fibroblasts in culture, Abstract;
TCF4 Is a Molecular Target of Resveratrol in the Prevention of Colorectal Cancer: J.B. Jeong, et al.; Int. J. Mol. Sci. 16, 10411 (2015), Application(s): Cell Culture, Abstract; Full Text
Poly(ADP-ribose) polymerase-1 promotes microglial activation, proliferation, and matrix metalloproteinase-9-mediated neuron death: T.M. Kauppinen & R.A. Swanson; J. Immunol. 174, 2288 (2005), Abstract; Full Text
Neuronal injury-induced expression and release of apolipoprotein E in mixed neuron/glia co-cultures: nuclear factor kappaB inhibitors reduce basal and lesion-induced secretion of apolipoprotein E: V. Petegnief, et al.; Neuroscience 104, 223 (2001), Abstract;
Inhibition of NF-kappaB induces apoptosis of KSHV-infected primary effusion lymphoma cells: S.A. Keller, et al.; Blood 96, 2537 (2000), Abstract;
Insulin-like growth factor-I protects colon cancer cells from death factor-induced apoptosis by potentiating tumor necrosis factor alpha- induced mitogen-activated protein kinase and nuclear factor kappaB signaling pathways: M.M. Remacle-Bonnet, et al.; Cancer Res. 60, 2007 (2000), Abstract;
Up-regulation of multidrug resistance P-glycoprotein via nuclear factor- kappaB activation protects kidney proximal tubule cells from cadmium- and reactive oxygen species-induced apoptosis: F. Thevenod, et al.; J. Biol. Chem. 275, 1887 (2000), Abstract; Full Text
Novel inhibitor of cytokine-induced IkBa phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo: J.W. Pierce, et al.; J. Biol. Chem. 272, 21096 (1997), Abstract; Full Text