Replaces Prod. #: ALX-270-021
Very potent protein kinase C (PKC) inhibitor with high selectivity for the PKC isotypes α and β. Inhibits PKCα (IC50=2.3nM) and PKCß1 (IC50=6.2nM) but has no effect on δ, ε or γ isotypes. Potent antagonist of HIV-1 induction.
Product Details
| Alternative Name: | 12-(2-Cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole |
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| Formula: | C24H18N4O |
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| MW: | 378.4 |
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| CAS: | 136194-77-9 |
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| Purity: | ≥95% (HPLC, TLC) |
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| Appearance: | Off-white to yellow solid. |
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| Solubility: | Soluble in DMSO (25mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stock solutions are stable for at least 3-4 months when stored at -20°C. |
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| Handling: | Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Pathobiology of renal-specific oxidoreductase/myo-inositol oxygenase in diabetic nephropathy: its implications in tubulointerstitial fibrosis: P. Xie, et al.; Am. J. Physiol. Renal Physiol.
298, F1393 (2010),
Abstract;
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Atypical isoforms of pKc and insulin secretion from pancreatic beta- cells: evidence using Go 6976 and Ro 31-8220 as Pkc inhibitors: T.E. Harris, et al.; BBRC
227, 672 (1996),
Abstract;
Inhibition of protein kinase C mu by various inhibitors. Differentiation from protein kinase c isoenzymes: M. Gschwendt, et al.; FEBS Lett.
392, 77 (1996),
Abstract;
N-protein kinase C isoenzymes may be involved in the regulation of various neutrophil functions: K. Wenzel-Seifert, et al.; BBRC
200, 1536 (1994),
Abstract;
Go 6976, a selective inhibitor of protein kinase C, is a potent antagonist of human immunodeficiency virus 1 induction from latent/low- level-producing reservoir cells in vitro: K.O. Qatsha, et al.; PNAS
90, 4674 (1993),
Abstract;
Non-glycosidic/non-aminoalkyl-substituted indolocarbazoles as inhibitors of protein kinase C: J. Kleinschroth, et al.; Bioorg. Med. Chem. Lett. 3, 1959 (1993),
Selective inhibition of protein kinase C isozymes by the indolocarbazole Go 6976: G. Martiny-Baron, et al.; J. Biol. Chem.
268, 9194 (1993),
Abstract;
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