Replaces Prod. #: ALX-270-137
A selective HER1-2 (HER2-Neu) tyrosine kinase inhibitor (IC50 = 0.35µM vs. 19µM for EGFR and 40µM for PDGFR). Not active in whole cells due to high intracellular ATP concentrations.
Product Details
| Alternative Name: | Tyrphostin AG 825, Tyrphostin C15, 5-[(Benzothiazol-2-yl)thiomethyl]-4-hydroxy-3-methoxybenzyl-idenecyanoacetamide |
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| Formula: | C19H15N3O3S2 |
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| MW: | 397.5 |
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| CAS: | 149092-50-2 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | Yellow solid. |
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| Solubility: | Soluble in DMSO (25mg/ml) or methanol. |
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| Shipping: | Ambient |
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| Long Term Storage: | Ambient |
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| Use/Stability: | Stable for at least 1 year after receipt when stored at +20°C. Stock solutions are stable for up to 3 months at -20°C. |
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| Handling: | Protect from light. |
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| Technical Info/Product Notes: | Note: Product is not sterile. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Tyrosine kinase inhibition: an approach to drug development: A. Levitzki & A. Gazit; Science
267, 1782 (1995),
Abstract;
Selective inhibition of the epidermal growth factor and HER2/neu receptors by tyrphostins: N. Osherov, et al.; J. Biol. Chem.
268, 11134 (1993),
Abstract;
