Suicide substrate for cytochrome P-450. Inhibits oxidative drug metabolism in vivo. Blocks ω-oxidation of arachidonic acid but not epoxidation.
Product Details
| Formula: | C6H6N4 |
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| MW: | 134.1 |
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| CAS: | 1614-12-6 |
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| Purity: | ≥98% (GC) |
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| Appearance: | White to gray to brown powder to crystal. |
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| Solubility: | Soluble in water. |
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| Shipping: | Ambient |
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| Long Term Storage: | Ambient |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
1-Aminobenzotriazole-induced destruction of hepatic and renal cytochromes P450 in male Sprague-Dawley rats: C. A. Mugford, et al.; Fundam. Appl. Toxicol.
19, 43 (1992),
Abstract;
In vivo inhibition of oxidative drug metabolism by, and acute toxicity of, 1-aminobenzotriazole (ABT). A tool for biochemical toxicology: B. A. Mico, et al.; Biochem. Toxicol.
37, 2515 (1988),
Abstract;
Inactivation of rabbit pulmonary cytochrome P-450 in microsomes and isolated perfused lungs by the suicide substrate 1-aminobenzotriazole: J. M. Mathews, et al.; J. Pharmacol. Exp. Ther.
235, 186 (1985),
Abstract;
