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United States 

Tyrphostin 46

Tyrosine kinase inhibitor
BML-EI257-0050 50 mg 249.00 USD
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Replaces Prod. #: ALX-270-131

Inhibits EGF receptor kinase (IC50=9.2 µM), p56lck (IC50=22 µM) and PDGF (IC50=50 µM) receptor kinase.

Product Details

Alternative Name:3,4-Dihydroxycyanocinnamide
Purity:≥98% (TLC)
Appearance:Brown solid.
Solubility:Soluble in DMSO (>25mg/ml) or 100% ethanol (5mg/ml warm).
Long Term Storage:Ambient
Handling:Store tightly sealed and protect from light. Make solutions fresh daily.
Regulatory Status:RUO - Research Use Only
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Product Literature References

Bicyclic compounds as ring-constrained inhibitors of protein-tyrosine kinase p56lck: T.R. Burke Jr., et al.; J. Med. Chem. 36, 425 (1993), Abstract;
T.R. Burke Jr., et al.; 204th National ACS Meeting Conference Proceedings (1992),
Tyrphostins as molecular tools and potential antiproliferative drugs: A. Levitzki & C. Gilon; Trends Pharmacol. Sci. 12, 171 (1991), Abstract;
Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors: A. Gazit, et al.; J. Med. Chem. 32, 2344 (1989), Abstract;