Replaces Prod. #: ALX-270-131
Inhibits EGF receptor kinase (IC50=9.2 µM), p56lck (IC50=22 µM) and PDGF (IC50=50 µM) receptor kinase.
Product Details
| Alternative Name: | 3,4-Dihydroxycyanocinnamide |
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| Formula: | C10H8N2O3 |
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| MW: | 204.2 |
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| CAS: | 122520-85-8 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | Brown solid. |
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| MeltingPoint: | 230-231°C |
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| Solubility: | Soluble in DMSO (>25mg/ml) or 100% ethanol (5mg/ml warm). |
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| Shipping: | Ambient |
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| Long Term Storage: | Ambient |
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| Handling: | Store tightly sealed and protect from light. Make solutions fresh daily. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Bicyclic compounds as ring-constrained inhibitors of protein-tyrosine kinase p56lck: T.R. Burke Jr., et al.; J. Med. Chem.
36, 425 (1993),
Abstract;
T.R. Burke Jr., et al.; 204th National ACS Meeting Conference Proceedings (1992),
Tyrphostins as molecular tools and potential antiproliferative drugs: A. Levitzki & C. Gilon; Trends Pharmacol. Sci.
12, 171 (1991),
Abstract;
Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors: A. Gazit, et al.; J. Med. Chem.
32, 2344 (1989),
Abstract;
