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Tyrosine kinase inhibitor
BML-EI252-0005 5 mg 122.00 USD
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Replaces Prod. #: ALX-270-148

RG-13022 is a non-phenolic tyrphostin analog, which inhibits the EGF receptor (IC50=5 µM) and PDGF receptor tyrosine kinases, and is long-acting. It inhibits EGF-stimulated HER14 cell proliferation (IC50=1 µM) as well as tumor growth in vivo. It inhibits both EGF- and PDGF-stimulated DNA synthesis in human glioma cell lines. RG-13022 is non-phenolic and therefore possesses less antioxidant activity than other tyrphostins.

Product Details

Alternative Name:3,4-Dimethoxy-α-(3-pyridyl)-(Z)-cinnamonitrile
Purity:≥98% (TLC)
Appearance:White solid.
Solubility:Soluble at 25mg/ml in DMSO or 100% ethanol.
Shipping:Ambient Temperature
Long Term Storage:Ambient
Use/Stability:Store, as supplied, at room temperature for up to 2 years. Store solutions at -20°C for up to 3 months.
Handling:Store tightly sealed in the dark. Protect from light.
Regulatory Status:RUO - Research Use Only
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Product Literature References

Inhibitors of protein tyrosine phosphorylation reduce the proliferation of two human glioma cell lines: P.A. Oude Weernink, et al.; Neurosurgery 38, 108 (1996), Abstract;
The antiproliferative effects of tyrosine kinase inhibitors tyrphostins on a human squamous cell carcinoma in vitro and in nude mice: T. Yoneda, et al.; Cancer Res. 51, 4430 (1991), Abstract;