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HNMPA-(AM)3

Insulin receptor inhibitor
 
BML-EI248-0005 5 mg 127.00 USD
 
BML-EI248-0025 25 mg 502.00 USD
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Replaces Prod. #: ALX-430-035

HNMPA-(AM)3 is a cell-permeable analog of HNMPA. It inhibits insulin receptor tyrosine kinase activity (IC50=100 µM) and insulin-stimulated glucose oxidation in isolated rat adipocytes (IC50=10 µM). It has no effect on PKA (at concs. up to 1 mM) or PKC (at concs. up to 420 µM). Inhibits both serine and tyrosine autophosphorylation by the human insulin receptor. Does not affect protein kinase C (PKC) or cAMP-dependent protein kinase (PKA).

Product Specification

Alternative Name:Hydroxy-2-naphthalenylmethylphosphonic acid tri-acetoxymethyl ester
 
Formula:C20H23O10P
 
MW:454.4
 
CAS:120944-03-8
 
Purity:≥98% (TLC)
 
Identity:Determined by NMR.
 
Appearance:Colorless oil.
 
Solubility:Soluble in DMSO (>20mg/ml) or 100% ethanol (>20mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Solutions are stable for up to 3 months whn stored at -20°C. Avoid alkaline medium, pH>8.0
 
Regulatory Status:RUO - Research Use Only
 
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Product Literature References

Insulin enhances striatal dopamine release by activating cholinergic interneurons and thereby signals reward: M.A. Stouffer, et al.; Nat. Commun. 6, 8543 (2018), Abstract; Full Text
Mechanism of action of camphoryl-benzene sulfonamide derivative on glucose uptake in adipose tissue: M.J.S. Frederico, et al.; J. Cell. Biochem. 119, 4408 (2018), Abstract;
A Small Insulinomimetic Molecule Also Improves Insulin Sensitivity in Diabetic Mice: S. Mukherjee, et al.; PLoS One 12, e0169809 (2017), Abstract; Full Text
Catalysis of serine and tyrosine autophosphorylation by the human insulin receptor: K. Bantensperger et al.; PNAS 89, 7885 (1992), Abstract;
Design of a selective insulin receptor tyrosine kinase inhibitor and its effect on glucose uptake and metabolism in intact cells: R. Saperstein et al.; Biochemistry 28, 5694 (1989), Abstract;

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