Replaces Prod. #: ALX-430-035
HNMPA-(AM)3 is a cell-permeable analog of HNMPA. It inhibits insulin receptor tyrosine kinase activity (IC50=100 µM) and insulin-stimulated glucose oxidation in isolated rat adipocytes (IC50=10 µM). It has no effect on PKA (at concs. up to 1 mM) or PKC (at concs. up to 420 µM). Inhibits both serine and tyrosine autophosphorylation by the human insulin receptor. Does not affect protein kinase C (PKC) or cAMP-dependent protein kinase (PKA).
Product Details
| Alternative Name: | Hydroxy-2-naphthalenylmethylphosphonic acid tri-acetoxymethyl ester |
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| Formula: | C20H23O10P |
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| MW: | 454.4 |
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| CAS: | 120944-03-8 |
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| Purity: | ≥98% (TLC) |
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| Identity: | Determined by NMR. |
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| Appearance: | Colorless oil. |
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| Solubility: | Soluble in DMSO (>20mg/ml) or 100% ethanol (>20mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Solutions are stable for up to 3 months whn stored at -20°C. Avoid alkaline medium, pH>8.0 |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Insulin enhances striatal dopamine release by activating cholinergic interneurons and thereby signals reward: M.A. Stouffer, et al.; Nat. Commun.
6, 8543 (2018),
Abstract;
Full Text
Mechanism of action of camphoryl-benzene sulfonamide derivative on glucose uptake in adipose tissue: M.J.S. Frederico, et al.; J. Cell. Biochem.
119, 4408 (2018),
Abstract;
A Small Insulinomimetic Molecule Also Improves Insulin Sensitivity in Diabetic Mice: S. Mukherjee, et al.; PLoS One
12, e0169809 (2017),
Abstract;
Full Text
Catalysis of serine and tyrosine autophosphorylation by the human insulin receptor: K. Bantensperger et al.; PNAS
89, 7885 (1992),
Abstract;
Design of a selective insulin receptor tyrosine kinase inhibitor and its effect on glucose uptake and metabolism in intact cells: R. Saperstein et al.; Biochemistry
28, 5694 (1989),
Abstract;
