HNMPA is a membrane impermeable inhibitor of insulin receptor tyrosine kinase (IC50 = 100µM); in rat adipocytes (IC50 = 10µM). Inhibits serine and tyrosine autophosphorylation by the human insulin receptor.
Product Details
Formula: | C11H11O4P |
|
MW: | 238.2 |
|
CAS: | 132541-52-7 |
|
Purity: | ≥98% (HPLC) |
|
Appearance: | White solid. |
|
MeltingPoint: | ≥250°C dec. |
|
Solubility: | Soluble in 100% ethanol (25mg/ml), DMSO (25ml/ml) or 5% Sodium bicarbonate (25mg/ml). |
|
Shipping: | Ambient Temperature |
|
Long Term Storage: | -20°C |
|
Use/Stability: | Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months. |
|
Regulatory Status: | RUO - Research Use Only |
|
Please mouse over
Product Literature References
Catalysis of serine and tyrosine autophosphorylation by the human insulin receptor: K. Baltensperger; Proc. Natl. Acad. Sci. USA
89, 7885 (1992),
Abstract;
Design of a selective insulin receptor tyrosine kinase inhibitor and its effect on glucose uptake and metabolism in intact cells: R. Saperstein et al.; Biochemistry
28, 5694 (1989),
Abstract;