HNMPA is a membrane impermeable inhibitor of insulin receptor tyrosine kinase (IC50 = 100µM); in rat adipocytes (IC50 = 10µM). Inhibits serine and tyrosine autophosphorylation by the human insulin receptor.
Product Details
| Formula: | C11H11O4P |
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| MW: | 238.2 |
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| CAS: | 132541-52-7 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | White solid. |
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| MeltingPoint: | ≥250°C dec. |
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| Solubility: | Soluble in 100% ethanol (25mg/ml), DMSO (25ml/ml) or 5% Sodium bicarbonate (25mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Catalysis of serine and tyrosine autophosphorylation by the human insulin receptor: K. Baltensperger; Proc. Natl. Acad. Sci. USA
89, 7885 (1992),
Abstract;
Design of a selective insulin receptor tyrosine kinase inhibitor and its effect on glucose uptake and metabolism in intact cells: R. Saperstein et al.; Biochemistry
28, 5694 (1989),
Abstract;
