Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 

R(-)-Deprenyl . HCl

Anti-apoptotic and neuroprotective
BML-EI240-0100 100 mg 66.00 USD
Do you need bulk/larger quantities?
Deprenyl inhibits apoptosis and displays neuroprotective effects in a variety of in vitro and in vivo systems. In vivo it rescues nigral dopaminergic neurons after systemic MPTP treatment. In vitro it rescues PC12 cells from apoptotic cell death induced by trophic withdrawal. The putative target responsible for the anti-apoptotic effects is glyceraldehyde-3-phosphate dehydrogenase. Deprenyl also inhibits monoamine oxidase-B, which is not involved in its anti-apoptotic mechanism. Parkinson’s disease therapeutic.

Product Details

Alternative Name:Selegiline hydrochloride
Formula:C13H17N . HCl
Purity:≥98% (HPLC)
Appearance:White solid.
Solubility:Soluble in water.
Shipping:Ambient Temperature
Long Term Storage:Ambient
Regulatory Status:RUO - Research Use Only
Please mouse over

Product Literature References

Glyceraldehyde-3-phosphate dehydrogenase, the putative target of the antiapoptotic compounds CGP 3466 and R-(-)-deprenyl: E. Kragten, et al.; J. Biol. Chem. 273, 5821 (1998), Abstract; Full Text
(-)-Deprenyl reduces PC12 cell apoptosis by inducing new protein synthesis: W. G. Tatton, et al.; J. Neurochem. 63, 1572 (1994), Abstract; Full Text
Rescue of dying neurons: a new action for deprenyl in MPTP parkinsonism: W. G. Tatton & C. E. Greenwood; J. Neurosci. Res. 30, 666 (1991), Abstract;
The effect of deprenyl (selegiline) on the natural history of Parkinson's disease: J. W. Tetrud & J. W. Langston; Science 245, 519 (1989), Abstract;

Related Literature

Download as PDF

All new literature pieces