Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 


Casein kinase inhibitor
BML-EI231-0050 50 mg 177.00 USD
Do you need bulk/larger quantities?
Replaces Prod. #: ALX-270-095

DRB is a potent and specific inhibitor of casein kinase II (CKII, IC50~6 µM). It has been used to inhibit RNA polymerase II mediated-transcription which may be dependent on CKII and its interaction with ATF-1.

Product Details

Alternative Name:DRB, 5,6-Dichlorobenzimidazole riboside
Purity:≥97% (TLC)
Identity:Determined by 1H-NMR.
Appearance:White solid.
Solubility:Soluble in DMSO (20mg/ml), 100% ethanol, and dimethyl formamide (100mM).
Long Term Storage:-20°C
Use/Stability:Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Regulatory Status:RUO - Research Use Only
Please mouse over

Product Literature References

Increased 14-3-3 phosphorylation observed in Parkinson's disease reduces neuroprotective potential of 14-3-3 proteins: S.R. Slone, et al.; Neurobiol. Dis. 79, 1 (2015), Application(s): Cell Culture, Abstract;
Histone hyperacetylation during SV40 transcription is regulated by p300 and RNA polymerase II translocation: L. Balakrishnan & B. Milavetz; J. Mol Biol. 371, 1022 (2007), Abstract; Full Text
RNA synthesis block by 5, 6-dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB) triggers p53-dependent apoptosis in human colon carcinoma cells: R.H. te Poele, et al.; Oncogene 18, 5765 (1999), Abstract; Full Text
Copurification of casein kinase II with transcription factor ATF/E4TF3: T. Wada, et al.; Nucleic Acids Res. 24, 876 (1996), Abstract;
Inhibition of germinal vesicle breakdown in bovine oocytes by 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB): C.E. Farin & L. Yang; Mol. Reprod. Dev. 37, 284 (1994), Abstract;
Kinetics of inhibition by 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole on calf thymus casein kinase II: R.O. Zandomeni; Biochem. J. 262, 469 (1989), Abstract;
Casein kinase type II is involved in the inhibition by 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole of specific RNA polymerase II transcription: R. Zandomeni, et al.; J. Biol. Chem. 261, 3414 (1986), Abstract;
Mechanism of action of 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole. II. A resistant human cell mutant with an altered transcriptional machinery: B. Mittleman, et al.; J. Mol. Biol. 165, 461 (1983), Abstract;
Mechanism of action of DRB. III. Effect on specific in vitro initiation of transcription: R. Zandomeni, et al. ; J. Mol. Biol. 167, 561 (1983), Abstract;
Halobenzimidazole ribosides and RNA synthesis of cells and viruses: I. Tamm & P.B. Sehgal; Adv. Virus Res. 22, 187 (1978), Abstract;

Product Toolbox


Certificate of Analysis


By target:
Casein kinase
By biological activity:
Casein kinase Inhibitor
By catalog section:


Technical Service
Customer Service

Related Literature

Integrated solutions for screening Wnt regulators
Integrated solutions for screening Wnt regulators
Download as PDF

All new literature pieces

Recommend this page

Keep in touch

©2022 Enzo Life Sciences, Inc.,