Replaces Prod. #: ALX-270-139
Member of the tyrphostin family of tyrosine kinase inhibitors. Selective inhibitor of the PDGF receptor kinase (IC50=20µM) vs. the EGF receptor kinase (IC50=820µM). Inhibits PDGF-induced mitogenesis in human bone marrow fibroblasts.
Product Details
| Alternative Name: | Tyrphostin AG 370, Tyrphostin B7, 2-Amino-4-(1H-indol-5-yl)-1,1,3-tricyanobuta-1,3-diene |
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| Formula: | C15H9N5 |
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| MW: | 287.3 |
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| CAS: | 134036-53-6 |
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| Purity: | ≥99% (TLC) |
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| Appearance: | Yellow solid. |
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| MeltingPoint: | 300-302°C |
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| Solubility: | Soluble in DMSO (25mg/ml) or 100% ethanol (2mg/ml, warm). |
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| Shipping: | Ambient |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stable for at least 1 year after receipt when stored at -20°C. Stock solutions are stable for up to 3 months at -20°C. |
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| Handling: | Store tightly sealed in the dark. Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Inhibition of platelet-derived growth factor-induced mitogenesis and tyrosine kinase activity in cultured bone marrow fibroblasts by tyrphostins: M.C. Bryckaert, et al.; Exp. Cell Res.
199, 255 (1992),
Abstract;
Inhibition of protein-tyrosine kinases by tyrphostins: A. Levitzki, et al.; Methods Enzymol.
201, 347 (1991),
Abstract;
