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Chelerythrine chloride

PKC inhibitor
BML-EI225-0005 5 mg 119.00 USD
BML-EI225-0025 25 mg 491.00 USD
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Replaces Prod. #: ALX-350-008

Reported to be a potent and selective inhibitor of protein kinase C (IC50=0.66µM). Although chelerythrine has numerous documented biological effects, studies have raised serious doubts about the effectiveness of chelerythrine as a PKC inhibitor.

Product Details

MI:14: 2051
Purity:≥98% (HPLC, TLC)
Appearance:Yellow solid.
Solubility:Soluble in DMSO, water (2mg/ml warm), 100% ethanol or methanol.
Shipping:Ambient Temperature
Long Term Storage:-20°C
Use/Stability:Heating to 40-50°C with gentle agitation may support complete solubilization. Further dilute with buffer just prior to use. Stock solutions should be refrigerated or frozen between for storage.
Regulatory Status:RUO - Research Use Only
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Product Literature References

MRCK-Alpha and Its Effector Myosin II Regulatory Light Chain Bind ABCB4 and Regulate Its Membrane Expression: A. Bruneau, et al.; Cells 11, 617 (2022), Abstract;
Follicle-Stimulating Hormone (FSH)-dependent Regulation of Extracellular Regulated Kinase (ERK) Phosphorylation by the Mitogen-activated Protein (MAP) Kinase Phosphatase MKP3: E.M. Donaubauer, et al.; J. Biol. Chem. 291, 19701 (2016), Application(s): Inhibition of MKP1 in Granulosa Cells, Abstract; Full Text
Chelerythrine and sanguinarine dock at distinct sites on BclXL that are not the classic BH3 binding cleft: Y.H. Zhang, et al.; J. Mol. Biol. 364, 536 (2006), Abstract;
The effect of chelerythrine on cell growth, apoptosis, and cell cycle in human normal and cancer cells in comparison with sanguinarine: J. Malikova, et al.; Cell Biol. Toxicol. 22, 439 (2006), Abstract;
Identification of chelerythrine as an inhibitor of BclXL function: S.L. Chan, et al.; J. Biol. Chem. 278, 20453 (2003), Abstract;
Induction of apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells by pharmacological inhibitors of protein kinase C: W.D. Jarvis, et al.; Cancer Res. 54, 1707 (1994), Abstract;
Antiplatelet effects of chelerythrine chloride isolated from Zanthoxylum simulans: F.N. Ko, et al.; Biochim. Biophys. Acta 1052, 360 (1990), Abstract;
Chelerythrine is a potent and specific inhibitor of protein kinase C: J.M. Herbert, et al.; BBRC 172, 993 (1990), Abstract;

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