Replaces Prod. #: ALX-350-008
Reported to be a potent and selective inhibitor of protein kinase C (IC50=0.66µM). Although chelerythrine has numerous documented biological effects, studies have raised serious doubts about the effectiveness of chelerythrine as a PKC inhibitor.
Product Details
| Formula: | C21H18ClNO4 |
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| MW: | 383.8 |
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| CAS: | 3895-92-9 |
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| MI: | 14: 2051 |
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| RTECS: | FL9200000 |
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| Purity: | ≥98% (HPLC, TLC) |
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| Appearance: | Yellow solid. |
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| Solubility: | Soluble in DMSO, water (2mg/ml warm), 100% ethanol or methanol. |
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| Shipping: | Ambient |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Heating to 40-50°C with gentle agitation may support complete solubilization. Further dilute with buffer just prior to use. Stock solutions should be refrigerated or frozen between for storage. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
MRCK-Alpha and Its Effector Myosin II Regulatory Light Chain Bind ABCB4 and Regulate Its Membrane Expression: A. Bruneau, et al.; Cells
11, 617 (2022),
Abstract;
Follicle-Stimulating Hormone (FSH)-dependent Regulation of Extracellular Regulated Kinase (ERK) Phosphorylation by the Mitogen-activated Protein (MAP) Kinase Phosphatase MKP3: E.M. Donaubauer, et al.; J. Biol. Chem.
291, 19701 (2016),
Application(s): Inhibition of MKP1 in Granulosa Cells,
Abstract;
Full Text
Chelerythrine and sanguinarine dock at distinct sites on BclXL that are not the classic BH3 binding cleft: Y.H. Zhang, et al.; J. Mol. Biol.
364, 536 (2006),
Abstract;
The effect of chelerythrine on cell growth, apoptosis, and cell cycle in human normal and cancer cells in comparison with sanguinarine: J. Malikova, et al.; Cell Biol. Toxicol.
22, 439 (2006),
Abstract;
Identification of chelerythrine as an inhibitor of BclXL function: S.L. Chan, et al.; J. Biol. Chem.
278, 20453 (2003),
Abstract;
Induction of apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells by pharmacological inhibitors of protein kinase C: W.D. Jarvis, et al.; Cancer Res.
54, 1707 (1994),
Abstract;
Antiplatelet effects of chelerythrine chloride isolated from Zanthoxylum simulans: F.N. Ko, et al.; Biochim. Biophys. Acta
1052, 360 (1990),
Abstract;
Chelerythrine is a potent and specific inhibitor of protein kinase C: J.M. Herbert, et al.; BBRC
172, 993 (1990),
Abstract;
