Inhibits prostacyclin synthase. Monoamine oxidase inhibitor. Effective small molecule inhibitor of histone demethylation. Inhibits the demethylase BHC110/LSD1 (IC50<2μM). When combined with a GSK-3 inhibitor, it causes reprogramming of human primary keratinocyte transduced with Oct4 and Klf4.
Product Details
| Alternative Name: | Trans(±)-2-phenylcyclopropanamine, SKF trans-355, Tranylcypromine hemisulfate |
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| Formula: | C9H11N . 1/2H2SO4 |
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| MW: | 182.2 |
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| CAS: | 13492-01-8 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | White solid. |
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| Solubility: | Soluble in water (25mg/ml). |
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| Shipping: | Ambient Temperature - Dangerous Good |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
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Application(s): Cell Culture,
Abstract;
Histone H3 lysine 4 demethylation is a target of nonselective antidepressive medications: M.G. Lee, et al.; Chem. Biol.
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Abstract;
Mechanism of inactivation of monoamine oxidase by 1-phenylcyclopropylamine:: R.B. Silverman & P.A. Zieske; Biochemistry
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Abstract;
