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Tranylcypromine

Demethylase inhibitor
 
BML-EI217-0001 1 g 117.00 USD
 
BML-EI217-0005 5 g 471.00 USD
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Inhibits prostacyclin synthase. Monoamine oxidase inhibitor. Effective small molecule inhibitor of histone demethylation. Inhibits the demethylase BHC110/LSD1 (IC50<2μM). When combined with a GSK-3 inhibitor, it causes reprogramming of human primary keratinocyte transduced with Oct4 and Klf4.

Product Specification

Alternative Name:Trans(±)-2-phenylcyclopropanamine, SKF trans-355, Tranylcypromine hemisulfate
 
Formula:C9H11N . 1/2H2SO4
 
MW:182.2
 
CAS:13492-01-8
 
Purity:≥98% (HPLC)
 
Appearance:White solid.
 
Solubility:Soluble in water (25mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Regulatory Status:RUO - Research Use Only
 
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Product Literature References

Targeting of PHOX2B expression allows the identification of drugs effective in counteracting neuroblastoma cell growth: E. D. Zanni, et al.; Oncotarget 8, 70695 (2017), Abstract; Full Text
Integrative genomics identifies YY1AP1 as an oncogenic driver in EpCAM+ AFP+ hepatocellular carcinoma: X. Zhao, et al.; Oncogene 34, 5095 (2015), Application(s): Cell Culture, Abstract;
Orphan nuclear receptor NR4A1 regulates transforming growth factor-β signaling and fibrosis: K. Palumbo-Zerr, et al.; Nat. Med. 21, 150 (2015), Application(s): Cell Culture, Abstract;
Histone H3 lysine 4 demethylation is a target of nonselective antidepressive medications: M.G. Lee, et al.; Chem. Biol. 13, 563 (2006), Abstract;
Mechanism of inactivation of monoamine oxidase by 1-phenylcyclopropylamine:: R.B. Silverman & P.A. Zieske; Biochemistry 24, 2128 (1985), Abstract;

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