Selective 12-lipoxygenase inhibitor. IC50=0.063 µM, 3.33 µM and 1.89 µM for 12-, 15- and 5-LO respectively in isolated enzyme preparations.
Product Details
| MW: | 321.3 |
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| CAS: | 132465-11-3 |
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| Purity: | ≥98% |
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| Solubility: | Soluble in ethanol (5mg/ml) or DMSO (5mg/ml). |
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| Shipping: | Ambient |
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| Long Term Storage: | Ambient |
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| Use/Stability: | Store, as supplied, at room temperature for up to 1 year. Store under nitrogen after opening. Product is subject to oxidation. Make solutions fresh daily. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Endogenously generated arachidonate-derived ligands for TRPV1 induce cardiac protection in sepsis: J. Chan, et al.; FASEB J.
32, 3816 (2018),
Application(s): Inhibition of 12(S)-HETE biosynthesis in mice,
Abstract;
Mechanisms underlying increased reactivity of pulmonary arteries contralateral to a localized high-flow anastomosis: S. Pfister, et al.; J. Thorac. Cardiovasc. Surg.
141, 425 (2011),
Abstract;
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