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Anti-arthritic agent
BML-EI206-0100 100 mg 153.00 USD
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Replaces Prod. #: ALX-430-064

Gold derivative. Widely used as an anti-arthritic drug. Inhibits various leukocyte activation pathways at multiple sites. Inhibits release of inflammatory mediators from human basophils, pulmonary mast cells and macrophages. Also inhibits human neutrophil 5-lipoxygenase. Inhibits IκB kinase (IKK) by modifying Cys179 of the IKKß subunit. Efficient inducer of mitochondrial membrane permeability transition pore in the presence of calcium ions, potentially referable to its inhibition of mitochondrial thioredoxin reductase.

Product Details

Alternative Name:SKF 39162, 1-Thio-β-D-glucopyranosatotriethyl phosphine gold-2,3,4,6-tetraacetate
MI:14: 878
Purity:≥98% (HPLC)
Appearance:White solid.
Solubility:Soluble in DMSO (5mg/ml) or 100% ethanol (4mg/ml).
Shipping:Ambient Temperature
Long Term Storage:Ambient
Use/Stability:Stable for at least 1 year after receipt when stored, as supplied, at room temperature. Stock solutions are stable for up to 3 months at -20°C.
Regulatory Status:RUO - Research Use Only
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Product Literature References

Regulation of Bax-dependent apoptosis by mitochondrial deubiquitinase USP30: D. Yan, et al.; Cell Death Discov. 1038, 41420 (2021), Abstract;
Validation of a human-serum-based in vitro growth method for drug screening on juvenile development stages of Schistosoma mansoni: V. Buchter, et al.; PLoS Negl. Trop. Dis. 15, 9313 (2021), Abstract; Full Text
The exceptional longevity of the naked mole-rat may be explained by mitochondrial antioxidant defenses: D. Munro, et al.; Aging Cell 18, e12916 (2019), Application(s): inhibitor for H2O2 consumption assay for TRX-dependent pathway, Abstract; Full Text
Deubiquitinase Inhibitor Auranofin Attenuated Cardiac Hypertrophy by Blocking NF-κB Activation: M. Hu, et al.; Cell Physiol. Biochem. 45, 2421 (2018), Abstract; Full Text
Evidence against Stable Protein S-Nitrosylation as a Widespread Mechanism of Post-translational Regulation: K. Wolhuter, et al.; Mol. Cell. 69, 438 (2018), Application(s): Inhibition of thioredoxin reductase in SMCs, Abstract;
Thioredoxin-Mimetic-Peptides Protect Cognitive Function after Mild Traumatic Brain Injury (mTBI): R. Baratz-Goldstein, et al.; PLoS One 11, e0157064 (2016), Application(s): MAPK Activity (human neuronal cells), Abstract; Full Text
Auranofin-induced oxidative stress causes redistribution of the glutathione pool in Taenia crassiceps cysticerci: J.J. Martínez-González, et al.; Mol. Biochem. Parasitol. 201, 16 (2015), Application(s): Cell Culture, Abstract;
Disruption of thioredoxin metabolism enhances the toxicity of transforming growth factor β-activated kinase 1 (TAK1) inhibition in KRAS-mutated colon cancer cells: J. E. Hrabe, et al.; Redox Biol. 5, 319 (2015), Application(s): Cell Culture, Abstract;
Repurposing auranofin as a lead candidate for treatment of lymphatic filariasis and onchocerciasis: C. A. Bulman, et al.; PLoS Negl. Trop. Dis. 9, e0003534 (2015), Application(s): Incubation, Abstract; Full Text
Suppressive Role of PPARγ-Regulated Endothelial Nitric Oxide Synthase in Adipocyte Lipolysis: Y. Yamada, et al.; PLoS One 10, e0136597 (2015), Application(s): Suppressed lipolysis, Abstract; Full Text
Gold drug auranofin could reduce neuroinflammation by inhibiting microglia cytotoxic secretions and primed respiratory burst: J.M. Maderira, et al.; J. Neuroimmunol. 276, 71 (2014), Application(s): Cell culture, Abstract;
Novel protective properties of auranofin: inhibition of human astrocyte cytotoxic secretions and direct neuroprotection: J.M. Maderira, et al.; Life Sci. 92, 1072 (2013), Application(s): Cell culture, Abstract;
Respiration-dependent H2O2 removal in brain mitochondria via the thioredoxin/peroxiredoxin system: D.A. Drechsel & M. Patel; J. Biol. Chem. 285, 27850 (2010), Abstract; Full Text
Induction of mitochondrial permeability transition by auranofin, a gold(I)-phosphine derivative: M.P. Rigobello, et al.; Br. J. Pharmacol. 136, 1162 (2002), Abstract;
Auranofin inhibits the activation pathways of polymorphonuclear leukocytes at multiple sites: R. Rudkowski, et al.; Biochem. Pharmacol. 41, 1921 (1991), Abstract;
Auranofin stimulates LTA hydrolase and inhibits 5-lipoxygenase/LTA synthase activity of isolated human neutrophils: W.H. Betts, et al.; Biochem. Pharmacol. 39, 1233 (1990), Abstract;
Modulation of mediator release from human basophils and pulmonary mast cells and macrophages by auranofin: M. Columbo, et al.; Biochem. Pharmacol. 39, 285 (1990), Abstract;
Antiarthritic gold compounds effectively quench electronically excited singlet oxygen: E.J. Corey, et al.; Science 236, 68 (1987), Abstract;