Replaces Prod. #: ALX-270-088
Potent and selective inhibitor of MLC kinase (Ki=0.3 µM). It inhibts also smooth-muscle myosin light chain kinase, protein kinase C (PKC) and cAMP-dependent protein kinase (PKA).
Product Details
| Alternative Name: | 1-(5-Iodonaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine . HCl |
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| Formula: | C15H17IN2O2S·HCl |
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| MW: | 452.7 |
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| CAS: | 110448-33-4 |
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| Purity: | ≥99% |
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| Appearance: | White solid. |
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| Solubility: | Soluble in DMSO (10mg/ml), ethanol/water (1:1, 10mg/ml), 100% ethanol (warm) and methanol. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C. |
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| Handling: | Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
LAP2β transmits force to upregulate genes via chromatin domain stretching but not compression: J. Sun, et al.; Acta Biomater.
163, 326 (2023),
Abstract;
Physical basis for the determination of lumen shape in a simple epithelium: C.G. Vasquez, et al.; Nat. Commun.
12, 5608 (2021),
Abstract;
Omegasome-proximal PtdIns(4,5)P2 couples F-actin mediated mitoaggregate disassembly with autophagosome formation during mitophagy: C.W. Hsieh, et al.; Nat. Commun.
10, 969 (2019),
Application(s): added during cell culture to screen for functional and structrual changes in mitophagy in HeLa cells expressing EBFP-2-Parkin, EGFP-dMito and KillerRed-dMito,
Abstract;
Full Text
Dysregulation in Actin Cytoskeletal Organization Drives Increased Stiffness and Migratory Persistence in Polyploidal Giant Cancer Cells: B. Xuan, et al.; Sci. Rep.
8, 11935 (2018),
Abstract;
Selective inhibition of catalytic activity of smooth muscle myosin light chain kinase: M. Saitoh, et al.; J. Biol. Chem.
262, 7796 (1987),
Abstract;
