Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 

ML-7 . HCl

Protein kinase inhibitor
BML-EI197-0010 10 mg 112.00 USD
BML-EI197-0050 50 mg 461.00 USD
Do you need bulk/larger quantities?
Replaces Prod. #: ALX-270-088

Potent and selective inhibitor of MLC kinase (Ki=0.3 µM). It inhibts also smooth-muscle myosin light chain kinase, protein kinase C (PKC) and cAMP-dependent protein kinase (PKA).

Product Details

Alternative Name:1-(5-Iodonaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine . HCl
Appearance:White solid.
Solubility:Soluble in DMSO (10mg/ml), ethanol/water (1:1, 10mg/ml), 100% ethanol (warm) and methanol.
Shipping:Ambient Temperature
Long Term Storage:-20°C
Use/Stability:Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Handling:Protect from light.
Regulatory Status:RUO - Research Use Only
Please mouse over

Product Literature References

LAP2β transmits force to upregulate genes via chromatin domain stretching but not compression: J. Sun, et al.; Acta Biomater. 163, 326 (2023), Abstract;
Physical basis for the determination of lumen shape in a simple epithelium: C.G. Vasquez, et al.; Nat. Commun. 12, 5608 (2021), Abstract;
Omegasome-proximal PtdIns(4,5)P2 couples F-actin mediated mitoaggregate disassembly with autophagosome formation during mitophagy: C.W. Hsieh, et al.; Nat. Commun. 10, 969 (2019), Application(s): added during cell culture to screen for functional and structrual changes in mitophagy in HeLa cells expressing EBFP-2-Parkin, EGFP-dMito and KillerRed-dMito, Abstract; Full Text
Dysregulation in Actin Cytoskeletal Organization Drives Increased Stiffness and Migratory Persistence in Polyploidal Giant Cancer Cells: B. Xuan, et al.; Sci. Rep. 8, 11935 (2018), Abstract;
Selective inhibition of catalytic activity of smooth muscle myosin light chain kinase: M. Saitoh, et al.; J. Biol. Chem. 262, 7796 (1987), Abstract;