Replaces Prod. #: ALX-270-068
An excellent affinity ligand for chromatographic purification of protein kinases. Inhibits protein kinases (Ki's: PKA=1.9 µM; PKC=18 µM; PKG=0.87 µM; MLCK=70 µM).
Product Details
| Alternative Name: | N-(2-Aminoethyl)-5-isoquinolinesulfonamide . HCl |
| |
| Formula: | C11H13N3O2S . HCl |
| |
| MW: | 287.8 |
| |
| CAS: | 116970-50-4 |
| |
| Purity: | ≥98% (TLC) |
| |
| Identity: | Determined by 1H-NMR. |
| |
| Appearance: | White solid. |
| |
| Solubility: | Soluble in water. |
| |
| Shipping: | Ambient Temperature |
| |
| Long Term Storage: | +4°C |
| |
| Use/Stability: | Stable for at least 1 year after receipt when stored, as supplied, at 0-4°C. Stock solutions are stable for up to 3 months at -20°C. |
| |
| Regulatory Status: | RUO - Research Use Only |
| |
Please mouse over
Product Literature References
Stimulation of phosphorylation of rat brush-border membrane proteins by Escherichia coli heat-stable enterotoxin, cholera enterotoxin and cyclic nucleotides, and its inhibition by protein kinase inhibitors, isoquinolinesulfonamides: T. Hirayama, et al.; Microb. Pathog.
8, 421 (1990),
Abstract;
Naphthalenesulfonamides as calmodulin antagonists and protein kinase inhibitors.: M. Inagaki, et al.; Mol. Pharmacol.
29, 577 (1986),
Abstract;
Interaction of protein kinase C with membranes is regulated by Ca2+, phorbol esters, and ATP.: M. Wolf, et al.; J. Biol. Chem.
260, 15718 (1985),
Abstract;
N-(2-Aminoethyl)-5-isoquinolinesulfonamide, a newly synthesized protein kinase inhibitor, functions as a ligand in affinity chromatography. Purification of Ca2+-activated, phospholipid-dependent and other protein kinases.: M. Inagaki, et al.; J. Biol. Chem.
260, 2922 (1985),
Abstract;
Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C: H. Hidaka, et al.; Biochemistry
23, 5036 (1984),
Abstract;
