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H-9 . HCl

PKA inhibitor
BML-EI195-0010 10 mg 108.00 USD
BML-EI195-0050 50 mg 437.00 USD
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Replaces Prod. #: ALX-270-068

An excellent affinity ligand for chromatographic purification of protein kinases. Inhibits protein kinases (Ki's: PKA=1.9 µM; PKC=18 µM; PKG=0.87 µM; MLCK=70 µM).

Product Details

Alternative Name:N-(2-Aminoethyl)-5-isoquinolinesulfonamide . HCl
Formula:C11H13N3O2S . HCl
Purity:≥98% (TLC)
Identity:Determined by 1H-NMR.
Appearance:White solid.
Solubility:Soluble in water.
Shipping:Ambient Temperature
Long Term Storage:+4°C
Use/Stability:Stable for at least 1 year after receipt when stored, as supplied, at 0-4°C. Stock solutions are stable for up to 3 months at -20°C.
Regulatory Status:RUO - Research Use Only
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Product Literature References

Stimulation of phosphorylation of rat brush-border membrane proteins by Escherichia coli heat-stable enterotoxin, cholera enterotoxin and cyclic nucleotides, and its inhibition by protein kinase inhibitors, isoquinolinesulfonamides: T. Hirayama, et al.; Microb. Pathog. 8, 421 (1990), Abstract;
Naphthalenesulfonamides as calmodulin antagonists and protein kinase inhibitors.: M. Inagaki, et al.; Mol. Pharmacol. 29, 577 (1986), Abstract;
Interaction of protein kinase C with membranes is regulated by Ca2+, phorbol esters, and ATP.: M. Wolf, et al.; J. Biol. Chem. 260, 15718 (1985), Abstract;
N-(2-Aminoethyl)-5-isoquinolinesulfonamide, a newly synthesized protein kinase inhibitor, functions as a ligand in affinity chromatography. Purification of Ca2+-activated, phospholipid-dependent and other protein kinases.: M. Inagaki, et al.; J. Biol. Chem. 260, 2922 (1985), Abstract;
Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C: H. Hidaka, et al.; Biochemistry 23, 5036 (1984), Abstract;