Replaces Prod. #: ALX-270-132
A potent inhibitor of EGF receptor kinase activity (IC50‘s:EGFR = 2.4 µM, PDGFR = 3.5 µM, p210bcr-abl=5.9 µM, insulin receptor = 640 µM).
Product Details
| Formula: | C10H8N2O2S |
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| MW: | 220.2 |
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| CAS: | 122520-86-9 |
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| Purity: | ≥99% (TLC) |
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| Appearance: | Orange solid. |
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| Solubility: | Soluble at 20 mg/ml in 100% ethanol or DMSO. |
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| Shipping: | Ambient |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Store, as supplied, at -20°C for up to 1 year. Product is subject to oxidation. Make solutions fresh daily. |
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| Handling: | Store tightly sealed in the dark. Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Tyrosine kinase inhibition: an approach to drug development: A. Levitsk & A. Gazit; Science
267, 1782 (1995),
Abstract;
Tyrphostins as molecular tools and potential antiproliferative drugs: A. Levitzki & C. Gilon; Trends Pharmacol. Sci.
12, 171 (1991),
Abstract;
Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors: A. Gazit, et al.; J. Med. Chem.
32, 2344 (1989),
Abstract;
Tyrphostins inhibit epidermal growth factor (EGF)-receptor tyrosine kinase activity in living cells and EGF-stimulated cell proliferation: R.M. Lyall, et al.; J. Biol. Chem.
264, 14503 (1989),
Abstract;
Blocking of EGF-dependent cell proliferation by EGF receptor kinase inhibitors: P. Yaish, et al.; Science
242, 933 (1988),
Abstract;
