Replaces Prod. #: ALX-270-070
Inhibits PKA and PKG selectively over PKC and MLCK. May be used in conjunction with H7 to probe for PKC-specific effects. Intracellular Ca2+ antagonist with no effect on cardiac function. Causes selective pulmonary vasodilation during pulmonary hypertension.
Product Details
| Alternative Name: | N-(2'-Guanidinoethyl)-5-isoquinolinesulfonamide . HCl |
| |
| Formula: | C12H15N5O2S . HCl |
| |
| MW: | 329.8 |
| |
| CAS: | 92564-34-6 |
| |
| Purity: | ≥98% (TLC) |
| |
| Identity: | Determined by 1H-NMR and MS. |
| |
| Appearance: | White to off-white solid. |
| |
| MeltingPoint: | 233-234°C |
| |
| Solubility: | Soluble in water (40mg/ml). |
| |
| Shipping: | Dry Ice |
| |
| Long Term Storage: | -20°C |
| |
| Use/Stability: | Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C. |
| |
| Handling: | Protect from light. |
| |
| Regulatory Status: | RUO - Research Use Only |
| |
Please mouse over
Product Literature References
Differential effects of isoquinolinesulfonamide protein kinase inhibitors on CA1 responses in hippocampal slices.: J.C. Leahy & M.L. Vallano; Neuroscience
44, 361 (1991),
Abstract;
Evidence that v-src and v-fps gene products use a protein kinase C-mediated pathway to induce expression of a transformation-related gene.: R. Spangler, et al.; Proc. Natl. Acad. Sci. USA
86, 7017 (1989),
Abstract;
Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C.: H. Hidaka, et al.; Biochemistry
23, 5036 (1984),
Abstract;
