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United States 

HA-1004 . HCl

PKA inhibitor
BML-EI184-0010 10 mg 117.00 USD
BML-EI184-0050 50 mg 477.00 USD
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Replaces Prod. #: ALX-270-070

Inhibits PKA and PKG selectively over PKC and MLCK. May be used in conjunction with H7 to probe for PKC-specific effects. Intracellular Ca2+ antagonist with no effect on cardiac function. Causes selective pulmonary vasodilation during pulmonary hypertension.

Product Details

Alternative Name:N-(2'-Guanidinoethyl)-5-isoquinolinesulfonamide . HCl
Formula:C12H15N5O2S . HCl
Purity:≥98% (TLC)
Identity:Determined by 1H-NMR and MS.
Appearance:White to off-white solid.
Solubility:Soluble in water (40mg/ml).
Shipping:Dry Ice
Long Term Storage:-20°C
Use/Stability:Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Handling:Protect from light.
Regulatory Status:RUO - Research Use Only
BML-EI184 structure
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BML-EI184 structure

Product Literature References

Differential effects of isoquinolinesulfonamide protein kinase inhibitors on CA1 responses in hippocampal slices.: J.C. Leahy & M.L. Vallano; Neuroscience 44, 361 (1991), Abstract;
Evidence that v-src and v-fps gene products use a protein kinase C-mediated pathway to induce expression of a transformation-related gene.: R. Spangler, et al.; Proc. Natl. Acad. Sci. USA 86, 7017 (1989), Abstract;
Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C.: H. Hidaka, et al.; Biochemistry 23, 5036 (1984), Abstract;