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N-(p-Amylcinnamoyl)anthranilic acid

Inhibitor of PLA2 and TRP channels
 
BML-EI178-0050 50 mg 92.00 USD
 
BML-EI178-0250 250 mg 345.00 USD
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ACA is a close structural analog of the PLA2 inhibitor, ONO-RS-082 and possesses similar but less potent inhibitory activity. Inhibits TRP channels independently of PLA2, including TRPM2, TRPC6 and TRPM8. It is a useful tool for studying the physiological role of TRP channels.

Product Specification

Alternative Name:ACA
 
Formula:C21H23NO3
 
MW:337.4
 
CAS:110683-10-8
 
Purity:≥99% (HPLC)
 
Appearance:White solid.
 
Solubility:Soluble in DMSO (50 mg/ml) or ethanol (50 mg/ml @ 60°C).
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
Use/Stability:Store, as supplied, at room temperature for up to 1 year. Make solutions fresh daily.
 
Regulatory Status:RUO - Research Use Only
 
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Product Literature References

Development and validation of a cell-based high-throughput screening assay for TRPM2 channel modulators: Y. Song, et al.; J. Biomol. Screen. 13, 54 (2008), Abstract;
N-(p-amylcinnamoyl)anthranilic acid (ACA): a phospholipase A(2) inhibitor and TRP channel blocker: C. Hartenec, et al.; Cardiovasc. Drug Rev. 25, 61 (2007), Abstract;
Inhibition of TRPM2 cation channels by N-(p-amylcinnamoyl)anthranilic acid: R. Kraft, et al.; Br. J. Pharmacol. 148, 264 (2006), Abstract; Full Text
Inhibition of glucose-induced insulin secretion by the diacylglycerol lipase inhibitor RHC 80267 and the phospholipase A2 inhibitor ACA through stimulation of K+ permeability without diminution by exogenous arachidonic acid: P. Thams & K. Capito; Biochem. Pharmacol. 53, 1077 (1997), Abstract;
Activation of phospholipases A and C in human platelets exposed to epinephrine: role of glycoproteins IIb/IIIa and dual role of epinephrine: H. S. Banga, et al.; Proc. Natl. Acad. Sci. USA 83, 9197 (1986), Abstract; Full Text

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