Replaces Prod. #: ALX-350-045
Marine sesterterpenoid. Irreversibly inhibits human synovial phospholipase A2 (PLA2, IC50=0.02-0.2µM depending on substrate) as well as bee (IC50=0.05µM) and cobra venom (IC50=2µM) PLA2 by covalently modifying lysine residues. Inhibits human recombinant sPLA2 (IC50=4.7µM) selectively over cPLA2. Also inhibits phospholipase C (PLC, IC50=1.5µM) and Ca2+ channels. Inhibits superoxide generation in polymorphonuclear leukocytes. Inhibits the release of arachidonate in cultured mouse peritoneal macrophages and in a mouse in vivo model. Has anti-inflammatory and analgesic properties. Shows strong quorum sensing antagonism.
Product Details
Formula: | C25H36O5 |
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MW: | 416.6 |
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CAS: | 75088-80-1 |
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Purity: | ≥98% (TLC) |
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Appearance: | Colorless to pale waxy or filmy residue. |
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Solubility: | Soluble in DMSO (25mg/ml), 100% ethanol (25mg/ml) or methanol. |
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Shipping: | Ambient |
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Long Term Storage: | -20°C |
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Use/Stability: | Stable for at least 1 year after receipt when stored at -20°C. Stock solutions are stable for up to 3 months at -20°C. |
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Regulatory Status: | RUO - Research Use Only |
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Product Literature References
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Application(s): Screening on Juvenile and adult zebrafish,
Abstract;
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Abstract;
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Abstract;
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Abstract;
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Abstract;
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Abstract;
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Abstract;
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Abstract;
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Abstract;
Regulation of eicosanoid biosynthesis in vitro and in vivo by the marine natural product manoalide: a potent inactivator of venom phospholipases: A.M. Mayer, et al.; J. Pharmacol. Exp. Ther.
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Abstract;
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Abstract;
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Abstract;
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Cobra venom phospholipase A2 inhibition by manoalide. A novel type of phospholipase inhibitor: D. Lombardo & E.A. Dennis; J. Biol. Chem.
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Abstract;