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Manoalide

Phospholipase inhibitor
 
BML-EI177-0001 1 mg 206.00 USD
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Replaces Prod. #: ALX-350-045

Marine sesterterpenoid. Irreversibly inhibits human synovial phospholipase A2 (PLA2, IC50=0.02-0.2µM depending on substrate) as well as bee (IC50=0.05µM) and cobra venom (IC50=2µM) PLA2 by covalently modifying lysine residues. Inhibits human recombinant sPLA2 (IC50=4.7µM) selectively over cPLA2. Also inhibits phospholipase C (PLC, IC50=1.5µM) and Ca2+ channels. Inhibits superoxide generation in polymorphonuclear leukocytes. Inhibits the release of arachidonate in cultured mouse peritoneal macrophages and in a mouse in vivo model. Has anti-inflammatory and analgesic properties. Shows strong quorum sensing antagonism.

Product Specification

Formula:C25H36O5
 
MW:416.6
 
CAS:75088-80-1
 
Purity:≥98% (TLC)
 
Appearance:Colorless to pale waxy or filmy residue.
 
Solubility:Soluble in DMSO (25mg/ml), 100% ethanol (25mg/ml) or methanol.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Stable for at least 1 year after receipt when stored at -20°C. Stock solutions are stable for up to 3 months at -20°C.
 
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Product Literature References

Quorum Sensing Antagonism from Marine Organisms: M.E. Skindersoe, et al.; Mar. Biotechnol. (NY) 10, 56 (2008), Abstract;
Manoalide: A. Soriente, et al.; Curr. Med. Chem. 6, 415 (1999), Review, Abstract;
Effect of manoalide on human 5-lipoxygenase activity: F. Cabre, et al.; Inflamm. Res. 45, 218 (1996), Abstract;
Identification of two specific lysines responsible for the inhibition of phospholipase A2 by manoalide: I.D. Bianco, et al.; Biochim. Biophys. Acta 1250, 197 (1995), Abstract;
Phospholipase A2 activation in cultured mouse hepatocytes exposed to tumor necrosis factor-alpha: G.M. Adamson, et al.; J. Biochem. Toxicol. 9, 181 (1994), Abstract;
Modulation of superoxide anion generation by manoalide, arachidonic acid and staurosporine in liver infiltrated neutrophils in a rat model of endotoxemia: A.M. Mayer & J.A. Spitzer; J. Pharmacol. Exp. Ther. 267, 400 (1993), Abstract;
Secretory phospholipase A2 inhibitors and calmodulin antagonists as inhibitors of cytosolic phospholipase A2: W. C. Hope, et al.; Agents Actions 39, C39 (1993), Abstract;
Inhibition of venom phospholipases A2 by manoalide and manoalogue. Stoichiometry of incorporation: L.J. Reynolds, et al.; J. Biol. Chem. 266, 16512 (1991), Abstract; Full Text
Inactivation of human synovial fluid phospholipase A2 by the marine natural product, manoalide: P.B. Jacobson, et al.; Biochem. Pharmacol. 39, 1557 (1990), Abstract;
Regulation of eicosanoid biosynthesis in vitro and in vivo by the marine natural product manoalide: a potent inactivator of venom phospholipases: A.M. Mayer, et al.; J. Pharmacol. Exp. Ther. 244, 871 (1988), Abstract;
Inactivation of bee venom phospholipase A2 by manoalide. A model based on the reactivity of manoalide with amino acids and peptide sequences: K.B. Glaser & R.S. Jacobs; Biochem. Pharmacol. 36, 2079 (1987), Abstract;
Manoalide, a natural sesterterpenoid that inhibits calcium channels: L.A. Wheeler, et al.; J. Biol. Chem. 262, 6531 (1987), Abstract; Full Text
Cobra venom phospholipase A2 inhibition by manoalide. A novel type of phospholipase inhibitor: D. Lombardo & E.A. Dennis; J. Biol. Chem. 260, 7234 (1985), Abstract;

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