Replaces Prod. #: ALX-270-098
Erbstatin is a novel inhibitor of the EGF receptor-associated tyrosine kinase. It is an unstable compound and is completely inactivated in serum in 30 minutes. Methyl 2,5-dihydroxycinnamate is a stable erbstatin analog retaining activity after a 60 minute incubation. It inhibits EGF receptor-associated tyrosine kinase in vitro (IC50=0.77 µM). Inhibition is competitive with substrate and noncompetitive with ATP.
Product Details
| Alternative Name: | Methyl 2,5-dihydroxycinnamate |
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| Formula: | C10H10O4 |
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| MW: | 194.2 |
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| CAS: | 63177-57-1 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | Yellow solid. |
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| MeltingPoint: | 169-172°C |
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| Solubility: | Soluble in ethanol (25mg/ml), methanol or DMSO (25mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | Ambient |
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| Use/Stability: | Stable for at least 1 year after receipt when stored, as supplied, at room temperature. Stock solutions are stable for up to 3 months at -20°C. |
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| Handling: | Protect from light and oxygen. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Induction of mouse thymocyte apoptosis by inhibitors of tyrosine kinases is associated with dephosphorylation of nuclear proteins: Y. Azuma, et al.; Cell. Immunol.
152, 271 (1993),
Abstract;
Inhibition of Abelson oncogene function by erbstatin analogues: M. Kawada, et al.; Drugs Exp. Clin. Res.
19, 235 (1993),
Abstract;
Inhibition of epidermal growth factor receptor functions by tyrosine kinase inhibitors in NIH3T3 cells: K. Umezawa, et al.; FEBS Lett.
314, 289 (1992),
Abstract;
Inhibition of epidermal growth factor-induced DNA synthesis by tyrosine kinase inhibitors: K. Umezawa, et al.; FEBS Lett.
260, 198 (1990),
Abstract;
In situ inhibition of tyrosine protein kinase by erbstatin: M. Imoto, et al.; Biochem. Int.
15, 989 (1987),
Abstract;
