A potent suicide inhibitor of cytochrome P450. Antipsoriatic activity following ultraviolet light exposure.
Product Details
| Alternative Name: | Xanthotoxin |
| |
| Formula: | C12H8O4 |
| |
| MW: | 216.2 |
| |
| CAS: | 298-81-7 |
| |
| Purity: | ≥98% (GC) |
| |
| Appearance: | White to yellow powder. |
| |
| Solubility: | Soluble in acetone or hot ethanol (slight). |
| |
| Shipping: | Ambient Temperature |
| |
| Long Term Storage: | Ambient |
| |
| Regulatory Status: | RUO - Research Use Only |
| |
Please mouse over
Product Literature References
The drug methoxsalen, a suicide substrate for cytochrome P-450, decreases the metabolic activation, and prevents the hepatotoxicity, of carbon tetrachloride in mice: G. Labbe, et al.; Biochem. Pharmacol.
36, 907 (1987),
Abstract;
Inactivation and induction of cytochrome P-450 by various psoralen derivatives in rats: P. Letteron, et al.; J. Pharmacol. Exp. Ther.
238, 685 (1986),
Abstract;
Oral methoxsalen photochemotherapy for the treatment of psoriasis: a cooperative clinical trial: J.W. Melski, et al.; J. Invest. Dermatol.
68, 328 (1977),
Abstract;
