Capsaicin

TRPV1 agonist



BML-EI125-0200	200 mg	138.00 USD

BML-EI125-1000	1 g	540.00 USD
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Replaces Prod. #: ALX-550-066

Capsaicin is an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. Exhibits neuroprotective effects in a model of transient global cerebral ischemia. Induces release of substance P from afferent nociceptive specific neurons. Constituent of cayenne pepper. Powerful excitant of peropheral sensory nerve endings, specifically unmyelinated afferent neurons (C-fibers). Reversibly inhibits aggregation of platelets.

Product Details

Alternative Name:	8-Methyl-N-vanillyl-6-nonenamide

Formula:	C₁₈H₂₇NO₃

MW:	305.4

Source:	Isolated from Capsicum fruit.

CAS:	404-86-4

Purity:	≥98% (TLC)

Appearance:	White to pale yellow.

Solubility:	Soluble in 100% ethanol, methanol or chloroform. Sparingly soluble in water.

Shipping:	Ambient

Long Term Storage:	Ambient

Use/Stability:	Store, as supplied, at room temperature for up to 2 years. Store solutions at -20°C for up to 3 months.

Regulatory Status:	RUO - Research Use Only

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Product Literature References

A Glucuronic Acid-Palmitoylethanolamide Conjugate (GLUPEA) Is an Innovative Drug Delivery System and a Potential Bioregulator: E. Manzo, et al.; Cells 450, 450 (2021), Abstract; Full Text

Inflammatory mediators modulating the transient receptor potential vanilloid 1 receptor: therapeutic targets to treat inflammatory and neuropathic pain: W. Ma & R. Quirion; Expert Opin. Ther. Targets 11, 307 (2007), Abstract;

Forty years in capsaicin research for sensory pharmacology and physiology: J. Szolcsanyi; Neuropeptides 38, 377 (2004), Abstract;

Capsaicin sensitive-sensory nerves and blood pressure regulation: P. Vaishnava & D.H. Wang; Curr. Med. Chem. Cardiovasc. Hematol. Agents 1, 177 (2003), Abstract;

Peppers and pain. The promise of capsaicin: B.M. Fusco & M. Giacovazzo ; Drugs 53, 909 (1997), Abstract;

Capsaicin, a double-edged sword: toxicity, metabolism, and chemopreventive potential: Y.J. Surth & S.S. Lee; Life. Sci. 56, 1845 (1995), Abstract;

Topical capsaicin. A review of its pharmacological properties and therapeutic potential in post-herpetic neuralgia, diabetic neuropathy and osteoarthritis: C. Rains & H.M. Bryson ; Drugs Aging 7, 317 (1995), Abstract;

Capsaicin: identification, nomenclature, and pharmacotherapy: G.A. Cordell & O.E. Araujo et al.; Ann. Pharmacother. 27, 330 (1993), Abstract;

Sensory neuron-specific actions of capsaicin: mechanisms and applications: S. Bevan & J. Szolcsanyi ; Trends Pharmacol. Sci. 11, 330 (1990), Abstract;

Role of tachykinins in neurogenic inflammation: B. Pernow ; J. Immunol. 135, 812s (1985), Abstract;