Replaces Prod. #: ALX-550-066
Capsaicin is an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. Exhibits neuroprotective effects in a model of transient global cerebral ischemia. Induces release of substance P from afferent nociceptive specific neurons. Constituent of cayenne pepper. Powerful excitant of peropheral sensory nerve endings, specifically unmyelinated afferent neurons (C-fibers). Reversibly inhibits aggregation of platelets.
Product Details
| Alternative Name: | 8-Methyl-N-vanillyl-6-nonenamide |
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| Formula: | C18H27NO3 |
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| MW: | 305.4 |
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| Source: | Isolated from Capsicum fruit. |
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| CAS: | 404-86-4 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | White to pale yellow. |
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| Solubility: | Soluble in 100% ethanol, methanol or chloroform. Sparingly soluble in water. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | Ambient |
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| Use/Stability: | Store, as supplied, at room temperature for up to 2 years. Store solutions at -20°C for up to 3 months. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
A Glucuronic Acid-Palmitoylethanolamide Conjugate (GLUPEA) Is an Innovative Drug Delivery System and a Potential Bioregulator: E. Manzo, et al.; Cells
450, 450 (2021),
Abstract;
Full Text
Inflammatory mediators modulating the transient receptor potential vanilloid 1 receptor: therapeutic targets to treat inflammatory and neuropathic pain: W. Ma & R. Quirion; Expert Opin. Ther. Targets
11, 307 (2007),
Abstract;
Forty years in capsaicin research for sensory pharmacology and physiology: J. Szolcsanyi; Neuropeptides
38, 377 (2004),
Abstract;
Capsaicin sensitive-sensory nerves and blood pressure regulation: P. Vaishnava & D.H. Wang; Curr. Med. Chem. Cardiovasc. Hematol. Agents
1, 177 (2003),
Abstract;
Peppers and pain. The promise of capsaicin: B.M. Fusco & M. Giacovazzo ; Drugs
53, 909 (1997),
Abstract;
Capsaicin, a double-edged sword: toxicity, metabolism, and chemopreventive potential: Y.J. Surth & S.S. Lee; Life. Sci.
56, 1845 (1995),
Abstract;
Topical capsaicin. A review of its pharmacological properties and therapeutic potential in post-herpetic neuralgia, diabetic neuropathy and osteoarthritis: C. Rains & H.M. Bryson ; Drugs Aging
7, 317 (1995),
Abstract;
Capsaicin: identification, nomenclature, and pharmacotherapy: G.A. Cordell & O.E. Araujo et al.; Ann. Pharmacother.
27, 330 (1993),
Abstract;
Sensory neuron-specific actions of capsaicin: mechanisms and applications: S. Bevan & J. Szolcsanyi ; Trends Pharmacol. Sci.
11, 330 (1990),
Abstract;
Role of tachykinins in neurogenic inflammation: B. Pernow ; J. Immunol.
135, 812s (1985),
Abstract;
