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Oleyloxyethyl phosphorylcholine

Phospholipase inhibitor
 
BML-EI118-0010 10 mg 75.00 USD
 
BML-EI118-0050 50 mg 266.00 USD
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A potent and specific substrate analog PLA2 inhibitor (IC50=6.2 µM-porcine pancreatic PLA2). It inhibits human recombinant sPLA2 (IC50=13.7 µM) selectively over cPLA2. At 1 µM it completely blocked the myogenic response in perfused dog renal arcuate arteries.

Product Specification

Formula:C25H52NO5P
 
MW:477.7
 
Source:Synthetic.
 
CAS:96720-06-8
 
Purity:≥98% (HPLC)
 
Appearance:Colorless oil or waxy solid.
 
Solubility:Soluble in 100% ethanol.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Regulatory Status:RUO - Research Use Only
 
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Product Literature References

Secretory phospholipase A2 inhibitors and calmodulin antagonists as inhibitors of cytosolic phospholipase A2: W.C. Hope, et al.; Agents Actions 39, C39 (1993), Abstract;
Inhibitors of cytochrome P-450 attenuate the myogenic response of dog renal arcuate arteries: K. Kauser, et al. ; Circulation Res. 68, 1154 (1991), Abstract; Full Text

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