Replaces Prod. #: ALX-340-008
Non-metabolizable analog of arachidonic or eicosadienoic acid. Cell permeable. DEDA inhibits P388D1 cell phospholipase A2 (PLA2) (IC50=16 µM) and snake venom PLA2 (IC50=14 µM). It inhibits human recombinant sPLA2 (IC50=5.8 µM) selectively over cPLA2. It is also a weak inhibitor of 5-lipoxygenase (IC50=56 µM, RBL-l cells). Inhibits induction of the anti-viral state in human fibroblasts induced by interferon.
Product Details
| Alternative Name: | DEDA |
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| Formula: | C22H40O2 |
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| MW: | 336.6 |
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| CAS: | 89560-01-0 |
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| Purity: | ≥99% |
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| Appearance: | Viscous colorless or pale yellow oil. |
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| Solubility: | Soluble in 100% ethanol or methanol. |
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| Shipping: | Ambient |
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| Long Term Storage: | +4°C |
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| Use/Stability: | Store, as supplied, at 4°C for up to 1 year. Store solutions at -20°C for up to 6 months. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Secretory phospholipase A2 inhibitors and calmodulin antagonists as inhibitors of cytosolic phospholipase A2: W.C. Hope, et al.; Agents Actions
39, C39 (1993),
Abstract;
Effect of the phospholipase A2 inhibitors quinacrine and 7,7-dimethyleicosadienoic acid in isolated globally ischemic rat hearts: C.A. Sargent, et al.; J. Pharmacol. Exp. Ther.
262, 1161 (1992),
Abstract;
Arachidonic acid regulates the binding of human interferon in human skin fibroblasts: S.D. Menon, et al.; Lipids
25, 321 (1990),
Abstract;
Inhibition studies on the membrane-associated phospholipase A2 in vitro and prostaglandin E2 production in vivo of the macrophage-like P388D1 cell. Effects of manoalide, 7,7-dimethyl-5,8-eicosadienoic acid, and p-bromophenacyl bromide: M.D. Lister, et al.; J. Biol. Chem.
264, 8520 (1989),
Abstract;
Analogs of arachidonic acid methylated at C-7 and C-10 as inhibitors of leukotriene biosynthesis: N. Cohen, et al.; Prostaglandins
27, 553 (1984),
Abstract;
