Leukotriene B4 antagonist. Inhibits binding of [3H]-LTB4 to guinea pig lung membranes (Ki=0.13 µM). Antagonizes the degranulation response to LTB4 in rabbit PMNL (Kd=0.2 µM) acting, most likely, via receptor desensitization. Partial agonist at higher concentrations (5 µM).
Product Details
| Formula: | C22H37NO3 |
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| MW: | 363.5 |
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| CAS: | 83024-92-4 |
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| Concentration: | 50 µg/ml |
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| Formulation: | Solution in ethanol. |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | Liquid. |
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| Shipping: | Shipped on Dry Ice |
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| Long Term Storage: | -80°C |
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| Use/Stability: | Store as supplied (-80°C) for up to two years. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Modulation of ligand binding to leukotriene B4 receptors on guinea pig lung membranes by sulfhydryl modifying reagents: R. C. Falcone & D. Aharony, et al.; J. Pharmacol. Exp. Ther.
155, 565 (1990),
Abstract;
