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(±)14,15-Epoxyeicosa-5Z,8Z,11Z-trienoic acid

COX inhibitor
BML-EE14-0050 50 µg 88.00 USD
BML-EE14-1000 1 mg 990.00 USD
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Stimulates glucagon release from rat pancreatic islets. Inhibits cyclooxygenase and platelet aggregation. Inhibits vasopressin response. Induces monocyte adhesion to endothelial cells. Inhibits renin release. Decreases blood pressure in rats.

Product Specification

Concentration:50µg/ml for 50µg size. 1mg/ml for 1mg size.
Formulation:Liquid. Solution in ethanol.
Shipping:Shipped on Dry Ice
Long Term Storage:-80°C
Use/Stability:Store, as supplied, at -80°C for up to 1 year.
Handling:Subject to oxidation - protect from air. Open ampule and aliquot into suitable tubes or vials. For experimenets with cells or tissues, aliquots of ethanol solutions may be added directly to aqueous media.
Regulatory Status:RUO - Research Use Only
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Product Literature References

14, 15-Epoxyeicosatrienoic acid promotes endothelial cell dependent adhesion of human monocytic tumor U937 cells: K. A. Pritchard, et al.; Biochem. Biophys. Res. Commun. 167, 137 (1990), Abstract;
Effect of 14,15-epoxyeicosatrienoic acid infusion on blood pressure in normal and hypertensive rats: W. K. Lin; Biochem. Biophys. Res. Commun. 167, 977 (1990), Abstract;
Inhibition of renin release by 14,15-epoxyeicosatrienoic acid in renal cortical slices: W. L. Henrich, et al.; Am. J. Physiol. 258, E269 (1990), Abstract;
Epoxygenase metabolites of arachidonic acid inhibit vasopressin response in toad bladder: D. Schlondorff, et al.; Am. J. Physiol. 253, F464 (1987), Abstract;
Inhibition of cyclooxygenase activity and platelet aggregation by epoxyeicosatrienoic acids. Influence of stereochemistry: F. A. Fitzpatrick, et al.; J. Biol. Chem. 261, 15334 (1986), Abstract;
Epoxyeicosatrienoic acids stimulate glucagon and insulin release from isolated rat pancreatic islets: J.R. Falck, et al.; BBRC 114, 743 (1983), Abstract;

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