FrPbAII is a component of the Parawixia bistriata spider venom. It has been shown to be a selective inhibitor of GABA and glycine uptake (IC50=65µM and 62µM respectively) with little or no effect on monoamine or glutamate transporters. It produces neuroprotective effects in a rat retinal ischemia/reperfusion model displaying remarkable reduction in cell death. It also abolishes convulsive tonic-clonic seizures induced by bicuculline (Prod. No. BML-EA149) in rats. Active in vivo. Crosses the blood-retina barrier.
Product Details
| Alternative Name: | L-2-Amino-5-ureidopentanamide |
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| Formula: | C6H14N4O2 . HCl |
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| MW: | 210.7 |
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| Purity: | ≥98% (NMR) |
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| Appearance: | Off-white solid. |
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| Solubility: | Soluble in water (>25mg/ml), DMSO (10mg/ml) or ethanol (25mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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