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mGluR antagonist
BML-EA147-0025 25 mg 660.00 USD
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Replaces Prod. #: ALX-550-325

A highly potent antagonist of the human group II and III metabotropic glutamate receptors (20-fold selectivity for group III mGluR and negligible activity at group I mGluR1. It reverses L-AP4 inhibition of forskolin-stimulated cAMP accumulation (IC50=2.2nM).

Product Details

Purity:≥98% (HPLC)
Appearance:White solid.
Solubility:Soluble in 100mM NaOH (27mg/100mM NaOH = 100mM stock at pH7).
Shipping:Ambient Temperature
Long Term Storage:Ambient
Use/Stability:Store, as supplied, at room temperature for up to 1 year. Store solutions at -20°C for up to 3 months.
Regulatory Status:RUO - Research Use Only
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Product Literature References

Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp, et al.; Neuropharmacology 38, 1431 (1999), Abstract;
Potent antagonists at the L-AP4- and (1S,3S)-ACPD-sensitive presynaptic metabotropic glutamate receptors in the neonatal rat spinal cord: D.E. Jane, et al.; Neuropharmacology 35, 1029 (1996), Abstract;
The effects of (RS)-alpha-cyclopropyl-4-phosphonophenylglycine ((RS)-CPPG), a potent and selective metabotropic glutamate receptor antagonist: N.J. Toms, et al.; Br. J. Pharmacol. 119, 851 (1996), Abstract;

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