Online Purchasing Account You are logged on as Guest. Login Register a New Account Shopping cart (Empty)

L-trans-Pyrrolidine-2,4-dicarboxylic acid

Glutamate transporter inhibitor



BML-EA139-0025	25 mg	574.00 USD
Do you need bulk/larger quantities?

Potent and selective glutamate uptake inhibitor.

Product Details

Formula:	C₆H₉NO₄

MW:	159.1

CAS:	64769-66-0

Purity:	≥98% (HPLC)

Identity:	Determined by ¹H-NMR and MS.

Appearance:	White solid.

Solubility:	Soluble in water (10 mg/ml).

Shipping:	Ambient Temperature

Long Term Storage:	Ambient

Regulatory Status:	RUO - Research Use Only

Please mouse over

Product Literature References

Comparison of Na+-dependent glutamate transport activity in synaptosomes, C6 glioma, and Xenopus oocytes expressing excitatory amino acid carrier 1 (EAAC1): L. A. Dowd, et al.; Mol. Pharmacol. 49, 465 (1996), Abstract;

Effects of L-trans-pyrrolidine-2,4-dicarboxylate and L-threo-3-hydroxyaspartate on the binding of [3H]L-aspartate, [3H]alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA), [3H]DL-(E)-2-amino-4-propyl-5-phosphono-3-pentenoate (CGP 39653), [3H]6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) and [3H]kainate studied by autoradiography in rat forebrain: V. J. Balcar, et al.; Neurochem. Int. 26, 155 (1995), Abstract;

L-trans-pyrrolidine-2,4-dicarboxylate and cis-1-aminocyclobutane-1,3-dicarboxylate behave as transportable, competitive inhibitors of the high-affinity glutamate transporters: R. Griffiths, et al.; Biochem. Pharmacol. 47, 267 (1994), Abstract;

Regional differences in the inhibition of L-glutamate and L-aspartate sodium-dependent high affinity uptake systems in rat CNS synaptosomes by L-trans-pyrrolidine-2,4-dicarboxylate, threo-3-hydroxy-D-aspartate and D-aspartate: A. D. Mitrovic & G. A. Johnston; Neurochem. Int. 24, 583 (1994), Abstract;

The neuronal and epithelial human high affinity glutamate transporter. Insights into structure and mechanism of transport: Y. Kanai, et al.; J. Biol. Chem. 269, 20599 (1994), Abstract; Full Text

Conformationally defined neurotransmitter analogues. Selective inhibition of glutamate uptake by one pyrrolidine-2,4-dicarboxylate diastereomer: R. J. Bridges, et al.; J. Med. Chem. 34, 717 (1991), Abstract;