Replaces Prod. #: ALX-550-045
Potent, competitive kainate/quisqualate (non-NMDA) receptor antagonist.
Product Details
Formula: | C8H4N4O6 |
|
MW: | 252.1 |
|
CAS: | 2379-57-9 |
|
Purity: | ≥98% (HPLC) |
|
Identity: | Determined by 1H-NMR and MS. |
|
Appearance: | Pale yellow solid. |
|
Solubility: | Soluble in DMSO (10mg/ml), acetone or methanol. |
|
Shipping: | Ambient |
|
Long Term Storage: | Ambient |
|
Use/Stability: | Store, as supplied, at room temperature for up to 1 year. Store solutions at 0-4°C for up to 3 months. |
|
Regulatory Status: | RUO - Research Use Only |
|
Please mouse over
Product Literature References
Stereochemistry of quinoxaline antagonist binding to a glutamate receptor investigated by Fourier transform infrared spectroscopy: D.R. Madden, et al.; J. Biol. Chem.
276, 37821 (2001),
Abstract;
Disulfide bonding and cysteine accessibility in the alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor subunit GluRD. Implications for redox modulation of glutamate receptors: R. Abele, et al.; J. Biol. Chem.
273, 25132 (1998),
Abstract;
6,7-Dichloroquinoxaline-2,3-dione is a competitive antagonist specific to strychnine-insensitive [3H]glycine binding sites on the N-methyl-D-aspartate receptor complex: K. Ogita & Y. Yoneda; J. Neurochem.
54, 699 (1990),
Abstract;
Noncompetitive excitatory amino acid receptor antagonists: D. Lodge & K.M. Johnson; Trends Pharmacol. Sci.
11, 81 (1990),
Abstract;
Abolition of the NMDA-mediated responses by a specifc glycine antagonist, 6,7-dichlorquinocaline-2,3-dione (DCQX): Y. Yoneda & K. Ogita; Biochem. Biophys. Res. Commun.
164, 841 (1989),
Abstract;
Excitatory amino acid receptors in the vertebrate central nervous system: G.L. Collingridge & R.A. Lester; Pharmacol. Rev.
41, 143 (1989),
Abstract;
Selectivity of quinoxalines and kynurenines as antagonists of the glycine site on N-methyl-D-aspartate receptors.: N.W. Kleckner & R. Dingledine; Mol. Pharmacol.
36, 430 (1989),
Abstract;
Contributions of quisqualate and NMDA receptors to the induction and expression of LTP: D. Muller, et al.; Science
242, 1694 (1988),
Abstract;
Quinoxalinediones: potent competitive non-NMDA glutamate receptor antagonists: T. Honoré, et al.; Science
241, 701 (1988),
Abstract;