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5,7-Dichlorokynurenic acid

NMDA receptor antagonist
BML-EA113-0010 10 mg 113.00 USD
BML-EA113-0050 50 mg 468.00 USD
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Replaces Prod. #: ALX-550-043

Potent antagonist at the NMDA receptor glycine site.

Product Details

Formula:C10H5Cl2NO3 . Na
Identity:Determined by NMR.
Appearance:Pale yellow solid.
Solubility:Soluble in water (10mg/ml), Water (insol.)
Long Term Storage:Ambient
Use/Stability:Store, as supplied, at room temperature for up to 1 year. Stotr dolutions at -20°C for up to 3 months,
Regulatory Status:RUO - Research Use Only
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Product Literature References

Kynurenic acid derivatives. Structure-activity relationships for excitatory amino acid antagonism and identification of potent and selective antagonists at the glycine site on the N-methyl-D-aspartate receptor: P.D. Leeson et al.; J. Med. Chem. 34, 1243 (1991), Abstract;
5,7-Dichlorokynurenic acid, a potent and selective competitive antagonist of the glycine site on NMDA receptors: D. McNamara et al.; Neurosci. Lett. 120, 17 (1990), Abstract;
Activity of 5,7.dichloroknurnic acid, a potent antagonist at the N-methyl-D-aspartate receptor-associated glycine binding site: B.M. Baron et al.; Mol. Pharmacol. 38, 554 (1990), Abstract;

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