Replaces Prod. #: ALX-550-043
Potent antagonist at the NMDA receptor glycine site.
Product Details
| Formula: | C10H5Cl2NO3 . Na |
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| MW: | 258.1 |
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| CAS: | 131123-76-7 |
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| Purity: | ≥98% |
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| Identity: | Determined by NMR. |
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| Appearance: | Pale yellow solid. |
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| Solubility: | Soluble in water (10mg/ml), Water (insol.) |
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| Shipping: | Ambient |
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| Long Term Storage: | Ambient |
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| Use/Stability: | Store, as supplied, at room temperature for up to 1 year. Stotr dolutions at -20°C for up to 3 months, |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Kynurenic acid derivatives. Structure-activity relationships for excitatory amino acid antagonism and identification of potent and selective antagonists at the glycine site on the N-methyl-D-aspartate receptor: P.D. Leeson et al.; J. Med. Chem.
34, 1243 (1991),
Abstract;
5,7-Dichlorokynurenic acid, a potent and selective competitive antagonist of the glycine site on NMDA receptors: D. McNamara et al.; Neurosci. Lett.
120, 17 (1990),
Abstract;
Activity of 5,7.dichloroknurnic acid, a potent antagonist at the N-methyl-D-aspartate receptor-associated glycine binding site: B.M. Baron et al.; Mol. Pharmacol.
38, 554 (1990),
Abstract;
