Replaces Prod. #: ALX-550-033
Active form of AP5. Potent NMDA receptor antagonist.
Product Details
| Alternative Name: | D(-)-2-Amino-5-phosphopentanoic acid |
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| Formula: | C5H12NO5P |
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| MW: | 197.1 |
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| CAS: | 79055-68-8 |
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| Purity: | ≥99% (HPLC) |
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| Identity: | Determined by 1H-NMR. |
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| Appearance: | White to off-white solid. |
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| Solubility: | Soluble in water (acidify for better solubility). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | Ambient |
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| Use/Stability: | Store, as supplied, at room temperature for up to 1 year. Store solutions at -20°C for up to 3 months. |
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| Handling: | Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
The NMDA receptor antagonist D-2-amino-5-phosphonopentanoate (D-AP5) impairs spatial learning and LTP in vivo at intracerebral concentrations comparable to those that block LTP in vitro: S. Davis et al.; J. Neurosci.
12, 21 (1992),
Abstract;
Structural, conformational, and stereochemical requirements of central excitatory amino acid receptors: J.J. Hansen & P. Krogsgaard-Larsen; Med. Res. Rev.
10, 55 (1990),
Abstract;
Actions of D and L forms of 2-amino-5-phosphonovalerate and 2-amino-4-phosphonobutyrate in the cat spinal cord: J. Davies & C. Watkins; Brain Res.
235, 378 (1982),
Abstract;
The effects of a series of omega-phosphonic alpha-carboxylic amino acids on electrically evoked and excitant amino acid-induced responses in isolated spinal cord preparations: R.H. Evans et al.; Br. J. Pharmacol.
75, 65 (1982),
Abstract;
2-Amino-5-phosphonovalerate (2APV), a potent and selective antagonist of amino acid-induced and synaptic excitation: J. Davies et al.; Neurosci. Lett.
21, 77 (1981),
Abstract;
Activity of the enantiomers of 2-amino-5-phosphono-valeric acid as stereospecific antagonists of excitatory aminoacids: T.W. Stone et al.; Neuroscience
6, 2249 (1981),
Abstract;
Excitatory amino acid transmitters: J.C. Watkins et al.; Annu. Rev. Pharmacol. Toxicol.
21, 165 (1981),
Abstract;
