Replaces Prod. #: ALX-300-300
In vitro potent activator of protein kinase C (PKC). Stimulator of secretion and aggregation in blood platelets. Stimulates formation of actin nucleation sites. Stimulation of pp60c-src phosphorylation in EBV transformed B-cells, 470μM.
Product Details
Alternative Name: | OAG |
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Formula: | C23H42O5 |
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MW: | 398.6 |
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Source: | Synthetic. |
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CAS: | 86390-77-4 |
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Purity: | ≥95% (TLC) |
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Appearance: | Colorless oil or waxy solid. |
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Solubility: | Soluble in DMSO or ethanol. |
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Shipping: | Shipped on Blue Ice |
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Long Term Storage: | -20°C |
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Use/Stability: | Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C. |
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Regulatory Status: | RUO - Research Use Only |
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Product Literature References
New patterns of diacylglycerol metabolism in intact cells: J. Florin-Christensen; Biochem. J.
289, 783 (1993),
Abstract;
Ca2+ and partly GTP gamma S-dependent particulate phospholipase C hydrolyzing phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate is inhibited by diacyl(acyl-acetyl) glycerols: E.W. Haeffner & U. Wittmann; J. Lipid Mediat.
5, 237 (1992),
Abstract;
Diacylglycerol-stimulated formation of actin nucleation sites at plasma membranes: A. Shariff & E.J. Luna; Science
256, 245 (1992),
Abstract;
Opposite effects of angiotensin II and the protein kinase C activator OAG on cardiac Na+ channels: I. Benz, et al.; J. Membr. Biol.
130, 183 (1992),
Abstract;
Structural requirements of diacylglycerols for binding and activating phospholipid-dependent, Ca++-sensitive protein kinase: D.E. Kerr, et al.; Biochem. Biophys. Res. Commun.
148, 776 (1987),
Abstract;
A possible role of protein kinase C in signal-induced lysosomal enzyme release: N. Kajikawa, et al.; BBRC
116, 743 (1983),
Abstract;
Ca2+ and protein kinase C: Two synergistic cellular signals: B. Michell; Trends Biochem. Sci. 8, 263 (1983), (Review),
Diacylglycerol and phorbol ester stimulate secretion without raising cytoplasmic free calcium in human platelets: T.J. Rink, et al.; Nature
305, 317 (1983),
Abstract;
Phorbol ester and diacylglycerol induce protein phosphorylation at tyrosine: T. Gilmore & G.S. Martin; Nature
306, 487 (1983),
Abstract;
Synergistic functions of protein phosphorylation and calcium mobilization in platelet activation: K. Kaibuchi, et al.; J. Biol. Chem.
258, 6701 (1983),
Abstract;
Full Text
Phosphatidylinositol turnover in platelet activation; calcium mobilization and protein phosphorylation: K. Kaibuchi, et al.; Cell Calcium
3, 323 (1982),
Abstract;
Specificity of the fatty acyl moieties of diacylglycerol for the activation of calcium-activated, phospholipid-dependent protein kinase: T. Mori, et al.; J. Biochem.
91, 427 (1982),
Abstract;