Product Specification
| Alternative Name: | CYP3A2 |
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| Host: | Rabbit |
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| Immunogen: | Synthetic peptide corresponding to a portion of C-terminal rat CYP3A21. |
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| UniProt ID: | P05183 |
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| Species reactivity: | Rat
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| Specificity: | Recognizes rat CYP3A2. Not suitable for use on human tissue. |
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| Applications: | IHC (FS), IHC (PS), WB
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| Shipping: | Shipped on Blue Ice |
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| Long Term Storage: | -20°C |
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| Scientific Background: | Members of the cytochrome P-450 3A (CYP3A) sub-family catalyze the 6β-hydroxylation of testosterone, and the metabolism of a number of drugs such as cyclosporin A (Prod. No. BML-A195), and warfarin. They are inducible by glucocorticoids such as dexamethasome (Prod. No. BML-EI126) and by macrolide antibiotics such as erythromycin and pregnenolone 16α-carbonitrile (U-14975, PCN) (Prod. No. BML- S620). Rat CYP3A1 and CPY3A2 share 89% sequence similarity at the amino acid level and are predominantly located in the liver, principally in the centrilobular region. PCN induces CYP3A1/2 gene expresion in regions of the liver. |
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For Research Use Only. Not for use in diagnostic procedures.
