| Alternative Name: | CYP2B6 |
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| Host: | Sheep |
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| Immunogen: | Synthetic peptide corresponding to aa 265-276 of human liver CYP2B6. |
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| UniProt ID: | P20813 |
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| Species reactivity: | Human
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| Specificity: | Recognizes human wild-type CYP2B6.1 and all known varients of CYP2B6. |
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| Applications: | IHC (FS), IHC (PS), WB
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| Formulation: | Liquid. Neat serum containing no preservative. |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Scientific Background: | Phenobarbital is well established as a potent inducer of cytochrome P-450 2B (CYP2B) expression, and work by different groups has shown that AP-1 might play a role in the induction process, and that insulin is able to supress the effect of phenobarbital. Human CYP2B6 appears to be the primary enzyme involved in the N-demethylation of S-mephenytoin and may contribute to the hepatic metabolism of toluene to benzyl alcohol. |
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| Regulatory Status: | RUO - Research Use Only |
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