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Cytochrome P450 1A2 (human) polyclonal antibody

BML-CR3130-0025 25 µl 119.00 USD
BML-CR3130-0100 100 µl 456.00 USD
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Product Details

Alternative Name:CYP1A2
Immunogen:Synthetic peptide corresponding to the internal domain (aa 284-298) of human CYP1A2.
UniProt ID:P05177
Species reactivity:Human
Specificity:Recognizes human CYP1A1. Not suitable for use on rat tissue.
Applications:IHC (FS), IHC (PS), WB
Blocking Peptide:For Blocking peptide see Prod. No. BML-CP0123.
Formulation:Liquid. Serum containing 0.01% sodium azide.
Shipping:Blue Ice
Long Term Storage:-20°C
Scientific Background:Members of the cytochrome P-450 1A (CYP1A) sub-family are induced by a range of polycyclic aromatic compounds such as benzpyrene, 3-methylcholanthrene (Prod. No. BML-GR239), and pro-carcinogenic heterocyclic aromatic amines. Cigarette smoking has been reported to induce CYP1A2 in human liver, and appears to be a major catalyst in the hepatic activation of PhIP, (2-amino-1-methyl-6-phenylimidazo[4,5,b]-pyridine). The mono-oxygenase inhibitor inhibitor enoxacin induces CYP1A2 in rat liver, whereas a related compound ciprofloxacin does not.
Regulatory Status:RUO - Research Use Only

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