Replaces Prod. #: ALX-270-239
Cannabinoid CB1 receptor antagonist (Ki=7.5 nM). Displays a high level of selectivity (306-fold) for CB1 over CB2 receptors. Structurally related to the cannabinoid receptor (CB) antagonist SR 141716A.
Product Details
Formula: | C22H21Cl2IN4O |
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MW: | 555.2 |
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CAS: | 183232-66-8 |
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Purity: | ≥98% (HPLC) |
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Identity: | Determined by 1H-NMR. |
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Appearance: | White to Off White |
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Solubility: | Soluble in DMSO, 100% ethanol or dimethyl formamide. |
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Shipping: | Ambient |
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Long Term Storage: | +4°C |
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Use/Stability: | Store, as supplied, at room temperature for up to 1 year. Store solutions at -20°C for up to 3 months. |
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Regulatory Status: | RUO - Research Use Only |
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Product Literature References
AM 251 produces sustained reductions in food intake and body weight that are resistant to tolerance and conditioned taste aversion: A.P. Chambers et al.; Br. J. Pharmacol.
147, 109 (2006),
Abstract;
Anxiogenic profile of AM-251, a selective cannabinoid CB1 receptor antagonist, in plus-maze-naive and plus-maze-experienced mice: R.J. Rodgers et al.; Behav. Pharmacol.
16, 405 (2005),
Abstract;
The cannabinoid 1 receptor antagonist, AM251, prolongs the survival of rats with severe acute pancreatitis: K. Matsuda et al.; Tohoku. J. Exp. Med.
207, 99 (2005),
Abstract;
The cannabinoid CB1 antagonist AM 251 produces food avoidance and behaviors associated with nausea but does not impair feeding efficiency in rats: P.J. McLaughlin et al.; Psychopharmacology (Berl)
180, 286 (2005),
Abstract;
Cannabinoid (CB)1 receptor antagonist, AM 251, causes a sustained reduction of daily food intake in the rat: A.P. Chambers et al.; Physiol. Behav.
82, 863 (2004),
Abstract;
Inhibition of voltage-sensitive sodium channels by the cannabinoid 1 receptor antagonist AM 251 in mammalian brain: C. Liao et al.; Basic Clin. Pharmacol. Toxicol.
94, 73 (2004),
Abstract;
Structure-activity relationships of pyrazole derivatives as cannabinoid receptor antagonists: R. Lan et al.; J. Med. Chem.
42, 769 (1999),
Abstract;
Binding of the non-classical cannabinoid CP 55,940, and the diarylpyrazole AM251 to rodent brain cannabinoid receptors: S. J. Gatley et al.; Life. Sci.
61, PL 191-7 (1997),
Abstract;