Replaces Prod. #: ALX-270-241
Acts as a cannabinoid receptor antagonist in mouse brain, vas deferens and guinea pig brain, but an agonist in guinea pig ileum. Acts as an inverse agonist on cloned human CB1 receptors.
Product Details
| Formula: | C23H25IN2O3 |
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| MW: | 504.4 |
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| CAS: | 164178-33-0 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | White to off-white solid. |
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| Solubility: | Soluble in DMSO or dimethyl formamide. |
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| Shipping: | Ambient |
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| Long Term Storage: | -20°C |
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| Handling: | Store under inert gas and avoid exposure to light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Activation of murine microglial N9 cells is attenuated through cannabinoid receptor CB2 signaling: L. Ma, et al.; Biochem. Biophys. Res. Commun.
458, 92 (2015),
Application(s): Cell Culture,
Abstract;
Effects of the cannabinoid antagonists AM281 and AM630 on deprivation-induced intake in Lewis rats: N.A. Werner & J.E. Koch; Brain Res.
967, 290 (2003),
Abstract;
Agonist-inverse agonist characterization at CB1 and CB2 cannabinoid receptors of L759633, L759656, and AM630: R.A. Ross et al.; Br. J. Pharmacol.
126, 665 (1999),
Abstract;
AM630 is an inverse agonist at the human cannabinoid CB1 receptor: R.S. Landsman et al.; Life Sci.
62, PL109 (1998),
Abstract;
AM630 is a competitive cannabinoid receptor antagonist in the guinea pig brain: K. Hosohata et al.; Life Sci.
61, PL115 (1997),
Abstract;
AM630, a competitive cannabinoid receptor antagonist: R. Pertwee et al.; Life Sci
56, 1949 (1995),
Abstract;
