Replaces Prod. #: ALX-270-242
Cannabinoid CB1 and CB2 agonist which is more potent than δ9-THC. Kd’s for cloned/transfected CB1 and CB2: 2.6 & 3.7 nM. Has been reported to induce the immediate early gene Krox-24 in corpus striatum and cultured astrocytes. Stimulates proliferation of stimulated B-cells at low nM concentrations.
Product Details
| Formula: | C24H40O3 |
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| MW: | 376.6 |
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| CAS: | 83002-04-4 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | White solid. |
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| Solubility: | Soluble in DMSO (4mg/ml) or ethanol. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Store, as supplied, for up to 1 year. Store solutions at -20°C for up to 3 months. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
The central cannabinoid receptor (CB1) mediates inhibition of nitric oxide production by rat microglial cells: Y. Waksman et al.; J. Pharmacol. Exp. Ther.
288, 1357 (1999),
Abstract;
Comparative receptor binding analyses of cannabinoid agonists and antagonists: B.F. Thomas et al.; J. Pharmacol. Exp. Ther.
285, 285 (1998),
Abstract;
Cannabinoids enhance human B-cell growth at low nanomolar concentrations: J.M. Derocq et al.; FEBS Lett.
369, 177 (1995),
Abstract;
Comparison of the pharmacology and signal transduction of the human cannabinoid CB1 and CB2 receptors: C.C. Felder et al.; Mol. Pharmacol.
48, 443 (1995),
Abstract;
Discriminative stimulus effects of CP 55,940 and structurally dissimilar cannabinoids in rats: J.L. Wiley et al.; Neuropharmacology
34, 669 (1995),
Abstract;
Induction of the Krox 24 transcription factor in striosomes by a cannabinoid agonist: M. Glass & M. Dragunow ; Neuroreport
6, 241 (1995),
Abstract;
Stimulation of cannabinoid receptor CB1 induces krox-24 expression in human astrocytoma cells: M. Bouaboula et al.; J. Biol. Chem.
270, 13973 (1995),
Abstract;
