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[G364S, P370L]Catestatin (human)

BML-CP6435-0001 1 mg 309.00 USD
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Human Chromogranin A [352-372, G364S, P370L]. A synthetic variant of catestatin incorporating the two known nucleotide polymorphic substitutions occurring in the human population. There are no data available concerning the effect of this double amino acid substitution.

Product Details

Alternative Name:[G364S, P370L]Chromogranin A (352-372)
Sequence:H-Ser-Ser-Met-Lys-Leu-Ser-Phe-Arg-Ala-Arg-Ala-Tyr-Ser-Phe-Arg-Gly-Leu-Gly-Pro-Gln-Leu-OH (human Chromogranin A[352-372, G364S, P370L])
Purity:≥98% (HPLC)
Appearance:White solid.
Solubility:Soluble in Water.
Shipping:Shipped on Blue Ice
Long Term Storage:-20°C
Regulatory Status:RUO - Research Use Only

Product Literature References

Both rare and common polymorphisms contribute functional variation at CHGA, a regulator of catecholamine physiology: G. Wen, et al.; Am. J. Human Genet. 74, 197 (2004), Abstract; Full Text
Formation of the catecholamine release-inhibitory peptide catestatin from chromogranin A. Determination of proteolytic cleavage sites in hormone storage granules: C.V. Taylor, et al.; J. Biol. Chem. 275, 22905 (2000), Abstract; Full Text
Novel autocrine feedback control of catecholamine release. A discrete chromogranin a fragment is a noncompetitive nicotinic cholinergic antagonist: S.K. Mahata, et al.; J. Clin. Invest. 100, 1623 (1997), Abstract; Full Text
Secretion from chromaffin cells is controlled by chromogranin A-derived peptides: J.P. Simon, et al.; Proc. Natl. Acad. Sci. USA 85, 1712 (1988), Abstract; Full Text
The primary structure of human chromogranin A and pancreastatin: D.S. Konecki, et al.; J. Biol. Chem. 262, 17026 (1987), Abstract; Full Text

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