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N(5)-(1-Iminoethyl)-L-ornithine . HCl

NOS inhibitor
 
BML-CN248-0010 10 mg 187.00 USD
 
BML-CN248-0050 50 mg 612.00 USD
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Replaces Prod. #: ALX-270-002

L-NIO is approximately 5 times more potent as an inhibitor of endothelial cell NO synthase than other arginine analogs such as L-NAME and L-NMMA. It inhibits NO production in endothelial cytosol (IC50=0.5µM), inhibits acetylcholine induced relaxation of rat aorta rings (IC50=2µM) and causes a dose-dependent increase in mean arterial blood pressure (EC50=19.5 mg/kg) in the rat. The product is not sterile.

Product Specification

Alternative Name:L-NIO
 
Formula:C7H15N3O2 . HCl
 
MW:209.7
 
CAS:150403-88-6
 
Purity:≥95% (TLC)
 
Identity:Determined by 1H-NMR and MS.
 
Appearance:White to off-white solid.
 
MeltingPoint:220-222°C
 
Solubility:Soluble in water (25mg/ml) or methanol (100mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Handling:Hygroscopic.
 
Regulatory Status:RUO - Research Use Only
 
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Product Literature References

Protective effects of inhibitors of nitric oxide synthase in immune complex-induced vasculitis.: M.S. Mulligan et al.; Br. J. Pharmacol. 107, 1159 (1992), Abstract;
Identification of N-iminoethyl-L-ornithine as an irreversible inhibitor of nitric oxide synthase in phagocytic cells.: T.B. McCall et al.; Br. J. Pharmacol. 102, 234 (1991), Abstract;
Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo.: D.D. Rees et al.; Br. J. Pharmacol. 101, 746 (1990), Abstract;
Nitric oxide from L-arginine stimulates the soluble guanylate cyclase in adrenal glands.: M. Palacios et al.; Biochem. Biophys. Res. Commun. 165, 802 (1989), Abstract;
Antimetabolites produced by microorganisms. VI. L-N 5 -(1-iminoethyl) ornithine.: J.P. Scannell et al.; J. Antibiot. (Tokyo) 25, 179 (1972), Abstract;

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