Replaces Prod. #: ALX-270-002
L-NIO is approximately 5 times more potent as an inhibitor of endothelial cell NO synthase than other arginine analogs such as L-NAME and L-NMMA. It inhibits NO production in endothelial cytosol (IC50=0.5µM), inhibits acetylcholine induced relaxation of rat aorta rings (IC50=2µM) and causes a dose-dependent increase in mean arterial blood pressure (EC50=19.5 mg/kg) in the rat. The product is not sterile.
Product Details
| Alternative Name: | L-NIO |
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| Formula: | C7H15N3O2 . HCl |
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| MW: | 209.7 |
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| CAS: | 150403-88-6 |
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| Purity: | ≥95% (TLC) |
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| Identity: | Determined by 1H-NMR and MS. |
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| Appearance: | White to off-white solid. |
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| MeltingPoint: | 220-222°C |
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| Solubility: | Soluble in water (25mg/ml) or methanol (100mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Handling: | Hygroscopic. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Protective effects of inhibitors of nitric oxide synthase in immune complex-induced vasculitis.: M.S. Mulligan et al.; Br. J. Pharmacol.
107, 1159 (1992),
Abstract;
Identification of N-iminoethyl-L-ornithine as an irreversible inhibitor of nitric oxide synthase in phagocytic cells.: T.B. McCall et al.; Br. J. Pharmacol.
102, 234 (1991),
Abstract;
Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo.: D.D. Rees et al.; Br. J. Pharmacol.
101, 746 (1990),
Abstract;
Nitric oxide from L-arginine stimulates the soluble guanylate cyclase in adrenal glands.: M. Palacios et al.; Biochem. Biophys. Res. Commun.
165, 802 (1989),
Abstract;
Antimetabolites produced by microorganisms. VI. L-N 5 -(1-iminoethyl) ornithine.: J.P. Scannell et al.; J. Antibiot. (Tokyo)
25, 179 (1972),
Abstract;
