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Dibutyryl-cGMP

PKG activator



BML-CN215-0010	10 mg	126.00 USD

BML-CN215-0050	50 mg	506.00 USD
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Replaces Prod. #: ALX-480-046

A cell-permeable cGMP analog which preferentially activates cGMP-dependent protein kinase. Inhibits thrombin stimulated arachidonic acid release in human platelets. Cell permeable.

Product Details

Formula:	C₁₈H₂₃N₅O₉P . Na

MW:	484.4 . 23.0

CAS:	51116-00-8

Purity:	≥96%

Appearance:	White solid.

Solubility:	Soluble in water (100mg/ml). Also soluble in 100% ethanol, DMSO, dimethyl formamide or methanol.

Shipping:	Ambient Temperature

Long Term Storage:	-20°C

Use/Stability:	Make solutions fresh daily. Avoid pH >8.5.

Regulatory Status:	RUO - Research Use Only

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Product Literature References

NF-κB Signaling Negatively Regulates Osteoblast Dedifferentiation during Zebrafish Bone Regeneration: R. Mishra, et al.; Dev. Cell 52, 167 (2020), Application(s): Screening on Juvenile and adult zebrafish, Abstract;

Claudin-19 mediates the effects of NO on the paracellular pathway in thick ascending limbs: C.M. Monzon & J.L. Garvin; Am. J. Physiol. Renal Physiol. 317, F411 (2019), Abstract;

Analysis of the functional role of cGMP-dependent protein kinase in intact human platelets using a specific activator 8-para-chlorophenylthio-cGMP: E. Butt, et al.; Biochem. Pharmacol. 43, 2591 (1992), Abstract;

Cyclic GMP analogs inhibit gamma thrombin-induced arachidonic acid release in human platelets: D.C. Sane, et al.; BBRC 165, 708 (1989), Abstract;

Relaxation of vascular and tracheal smooth muscle by cyclic nucleotide analogs that preferentially activate purified cGMP-dependent protein kinase: S.H. Francis, et al.; Mol. Pharmacol. 34, 506 (1988), Abstract;

’Relaxation of hormonally stimulated smooth muscular tissues by the 8-bromo derivative of cyclic GMP: K.D. Schultz, et al.; Naunyn Schmiedeberg's Arch. Pharmacol. 306, 1 (1979), Abstract;

Analogs of cyclic AMP and cyclic GMP: general methods of synthesis and the relationship of structure to enzymic activity: R.B. Meyer, Jr. & J.P. Miller; Life Sci. 14, 1019 (1974), Abstract;