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PKG activator
BML-CN215-0010 10 mg 129.00 USD
BML-CN215-0050 50 mg 521.00 USD
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Replaces Prod. #: ALX-480-046

A cell-permeable cGMP analog which preferentially activates cGMP-dependent protein kinase. Inhibits thrombin stimulated arachidonic acid release in human platelets. Cell permeable.

Product Details

Formula:C18H23N5O9P . Na
MW:484.4 . 23.0
Appearance:White solid.
Solubility:Soluble in water (100mg/ml). Also soluble in 100% ethanol, DMSO, dimethyl formamide or methanol.
Shipping:Ambient Temperature
Long Term Storage:-20°C
Use/Stability:Make solutions fresh daily. Avoid pH >8.5.
Regulatory Status:RUO - Research Use Only
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Product Literature References

NF-κB Signaling Negatively Regulates Osteoblast Dedifferentiation during Zebrafish Bone Regeneration: R. Mishra, et al.; Dev. Cell 52, 167 (2020), Application(s): Screening on Juvenile and adult zebrafish, Abstract;
Claudin-19 mediates the effects of NO on the paracellular pathway in thick ascending limbs: C.M. Monzon & J.L. Garvin; Am. J. Physiol. Renal Physiol. 317, F411 (2019), Abstract;
Analysis of the functional role of cGMP-dependent protein kinase in intact human platelets using a specific activator 8-para-chlorophenylthio-cGMP: E. Butt, et al.; Biochem. Pharmacol. 43, 2591 (1992), Abstract;
Cyclic GMP analogs inhibit gamma thrombin-induced arachidonic acid release in human platelets: D.C. Sane, et al.; BBRC 165, 708 (1989), Abstract;
Relaxation of vascular and tracheal smooth muscle by cyclic nucleotide analogs that preferentially activate purified cGMP-dependent protein kinase: S.H. Francis, et al.; Mol. Pharmacol. 34, 506 (1988), Abstract;
’Relaxation of hormonally stimulated smooth muscular tissues by the 8-bromo derivative of cyclic GMP: K.D. Schultz, et al.; Naunyn Schmiedeberg's Arch. Pharmacol. 306, 1 (1979), Abstract;
Analogs of cyclic AMP and cyclic GMP: general methods of synthesis and the relationship of structure to enzymic activity: R.B. Meyer, Jr. & J.P. Miller; Life Sci. 14, 1019 (1974), Abstract;

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