Replaces Prod. #: ALX-480-006
A cell-permeable cGMP analog which is more resistant to phosphodiesterases than cGMP and which preferentially activates cGMP-dependent protein kinase. It inhibits thrombin stimulated arachidonic acid release in human platelets.
Product Details
| Formula: | C10H10BrN5O7PNa |
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| MW: | 446.1 |
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| CAS: | 51116-01-9 |
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| Purity: | ≥96% (HPLC) |
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| Identity: | Determined by ESI-MS and UV/VIS. |
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| Appearance: | White to off-white powder |
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| Solubility: | Soluble in water (25mg/ml) or aqueous buffers. Sparingly soluble in methanol (4mM). Insoluble in DMSO, dimethyl formamide and 96% ethanol. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Endothelin-1 induces lipolysis through activation of the GC/cGMP/Ca2+/ERK/CaMKIII pathway in 3T3-L1 adipocytes: C.C. Lien, et al.; Biochim. Biophys. Acta Mol. Cell Biol. Lipids
1867, 159071 (2022),
Abstract;
Nitric oxide in skeletal muscle: L. Kobizik et al.; Nature
372, 546 (1994),
Abstract;
Nitric oxide. More jobs for that molecule: S. Snyder; Nature
372, 504 (1994),
Abstract;
The nitric oxide--cyclic GMP pathway and synaptic depression in rat hippocampal slices: C.L. Boulton et al.; Eur. J. Neurosci.
6, 1528 (1994),
Abstract;
Cyclic GMP analogs inhibit gamma thrombin-induced arachidonic acid release in human platelets: D.C. Sane et al.; Biochem. Biophys. Res. Commun.
165, 708 (1989),
Abstract;
Relaxation of vascular and tracheal smooth muscle by cyclic nucleotide analogs that preferentially activate purified cGMP-dependent protein kinase: S.G. Francis et al.; Mol. Pharmacol.
34, 506 (1988),
Abstract;
Interaction of hydrolysis-resistant analogs of cyclic GMP with the phosphodiesterase and light-sensitive channel of retinal rod outer segments: A.L. Zimemmerman et al.; PNAS
82, 8813 (1985),
Abstract;
Sodium nitroprusside-induced protein phosphorylation in intact rat aorta is mimicked by 8-bromo cyclic GMP: R.M. Rapoport et al.; PNAS
79, 6470 (1982),
Abstract;
Relaxation of hormonally stimulated smooth muscular tissues by the 8-bromo derivative of cyclic GMP: K. D. Schultz et al.; Naunyn-Schmiedebergs Arch. Pharmacol.
306, 1 (1979),
Abstract;
Analogs of cyclic AMP and cyclic GMP: general methods of synthesis and the relationship of structure to enzymic activity: R.B. Meyer Jr. & J.P. Miller; Life. Sci.
14, 1019 (1974),
Abstract;
