Replaces Prod. #: BML-CN150
Product Details
| Alternative Name: | AC toxin |
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| MW: | ~200 kDa |
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| Source: | Produced in E. coli. |
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| UniProt ID: | J7QLC0 |
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| Formulation: | Liquid. In 0.05M Tris-HCl and 8M Urea pH 8.0. |
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| Purity: | ≥80% (SDS-PAGE) |
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| Application Notes: | AC toxin is a unique tool for increasing cAMP levels in mammalian cells. |
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| Shipping: | Dry Ice |
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| Long Term Storage: | -20°C |
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| Handling: | After thawing, to ensure recovery of vial contents, centrifuge before opening the tube. Aseptic handling is recommended, no preservatives have been added to the product. Avoid freeze/thaw cycles. |
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| Scientific Background: | AC toxin inserts itself into the membrane of target cells and delivers its adenylate cyclase enzymatic domain to the cell interior. Its adenylate cyclase activity is then stimulated by endogenous Ca2+ and calmodulin. The resulting increase in cAMP concentration can easily reach supraphysiological levels. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Synthesis of α‐branched acyclic nucleoside phosphonates as potential inhibitors of bacterial adenylate cyclases: J. Frydrych, et al.; ChemMedChem.
13, 199 (2018),
Abstract;
