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United States 

Adenylate cyclase toxin

Increases intracellular cAMP levels
BML-CN150A-0050 50 µg 654.00 USD
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Replaces Prod. #: BML-CN150

Product Details

Alternative Name:AC toxin
MW:~200 kDa
Source:Produced in E. coli.
UniProt ID:J7QLC0
Formulation:Liquid. In 0.05M Tris-HCl and 8M Urea pH 8.0.
Purity:≥80% (SDS-PAGE)
Application Notes:AC toxin is a unique tool for increasing cAMP levels in mammalian cells.
Shipping:Dry Ice
Long Term Storage:-20°C
Handling:After thawing, to ensure recovery of vial contents, centrifuge before opening the tube. Aseptic handling is recommended, no preservatives have been added to the product. Avoid freeze/thaw cycles.
Scientific Background:AC toxin inserts itself into the membrane of target cells and delivers its adenylate cyclase enzymatic domain to the cell interior. Its adenylate cyclase activity is then stimulated by endogenous Ca2+ and calmodulin. The resulting increase in cAMP concentration can easily reach supraphysiological levels.
Regulatory Status:RUO - Research Use Only

Product Literature References

Synthesis of α‐branched acyclic nucleoside phosphonates as potential inhibitors of bacterial adenylate cyclases: J. Frydrych, et al.; ChemMedChem. 13, 199 (2018), Abstract;

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By target:
Adenylate cyclase
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Adenylate cyclase Recombinant protein
Adenylate cyclase Enzyme
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