Replaces Prod. #: ALX-270-080
Adenylate cyclase inhibitor (IC50=250 µM).
Product Details
| Alternative Name: | cis-N-(2-Phenylcyclopentyl)azacyclotridec-1-en-2-amine . HCl |
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| Formula: | C23H36N2 . HCl |
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| MW: | 377 |
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| CAS: | 40297-09-4 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | White solid. |
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| Solubility: | Soluble in water (3mg/ml), DMSO (10mg/ml, slightly warm), 100% ethanol (>10mg/ml) and hot 0.1N HCl (0.5mg/ml); insoluble in 0.1N NaOH. |
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| Shipping: | Ambient |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Hydrogen peroxide stimulation of CFTR reveals an Epac-mediated, soluble AC-dependent cAMP amplification pathway common to GPCR signalling: P. Ivonnet, et al.; Br. J. Pharmacol.
172, 173 (2015),
Abstract;
Full Text
Melatonin biosynthesis in cultured chick retinal photoreceptor cells: calcium and cyclic AMP protect serotonin N-acetyltransferase from inactivation in cycloheximide-treated cells: A.L. Alonso-Gomez & P.M. Iuvone; J. Neurochem.
65, 1054 (1995),
Abstract;
Tonic adenosine A2A receptor activation modulates nicotinic autoreceptor function at the rat neuromuscular junction: P. Correia-de-Sa & J.A. Ribeiro; Eur. J. Pharmacol.
271, 349 (1994),
Abstract;
Actions of vasopressin and isoprenaline on the ionic transport across the isolated frog skin in the presence and the absence of adenyl cyclase inhibitors MDL12330A and SQ22536: C. Lippe & C. Ardizzone; Comp. Biochem. Physiol.
99, 209 (1991),
Abstract;
