Replaces Prod. #: ALX-480-049
A useful, cell-permeable inhibitor of adenylate cyclase (ID50=250µM). Inhibits growth and causes cell differentiation (1.5µM) in K562 cells.
Product Details
| Formula: | C10H13N5O2 |
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| MW: | 235.2 |
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| CAS: | 6698-26-6 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | White to off-white solid. |
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| Solubility: | Soluble in water (20mg/ml at 50°C) or DMSO (30mg/ml). |
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| Shipping: | Ambient |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Solutions are stable up to 3 months when stored at -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Erythroid differentiation and growth inhibition of K562 cells by 2’,5’-dideoxyadenosine: synergism with interferon-alpha: K. Ogawa et al.; Leuk. Res.
19, 749 (1995),
Abstract;
Direct inhibitory effect of neurotensin on isolated gastric smooth muscle cells of guinea pig via the cyclic GMP system: Y. Chijiiwa et al.; Digestion
54, 135 (1993),
Abstract;
Isoproterenol antagonistic effect of 2’,5’-dideoxyadenosine in the isolated perfused guinea-pig heart: M. Hartmann & J. Schrader; J. Mol. Cell. Cardiol.
25, 331 (1993),
Abstract;
I. BAggioni ; Am. J. Hypertens. 6, 1475 (1992),
Inhibition of adenylate cyclase attenuates adenosine receptor-mediated relaxation in coronary artery: M.H. Sabouni et al.; J. Pharmacol. Exp. Ther.
259, 508 (1991),
Abstract;
Role of adenylate cyclase in immunologic release of mediators from rat mast cells: agonist and antagonist effects of purine- and ribose-modified adenosine analogs: S.T. Holgate et al.; PNAS
77, 6800 (1980),
Abstract;
