A novel member of the spiro-piperidine class of M2 proton channel inhibitors similar to BL-1743. Displays increased potency (IC50=0.92µM) compared with amantadine.
Product Details
| Alternative Name: | 3-Azaspiro[5.5]undecane . HCl |
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| Formula: | C10H19N . HCl |
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| MW: | 153.2 . 36.5 |
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| CAS: | 180-44-9 |
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| Purity: | ≥97% (HPLC) |
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| Appearance: | White solid. |
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| Solubility: | Soluble in water (>25mg/ml), DMSO (>25mg/ml) or 100% ethanol (>25mg/ml). |
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| Shipping: | Ambient |
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| Long Term Storage: | Ambient |
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| Use/Stability: | Store, as supplied, at room temperature for up to 1 year. Store solutions at -20°C for up to 3 months. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Discovery of spiro-piperidine inhibitors and their modulation of the dynamics of the M2 proton channel from influenza A virus: J. Wang, et al.; J. Am. Chem. Soc.
131, 8066 (2009),
Abstract;
Characterization of inhibition of M2 ion channel activity by BL-1743, an inhibitor of influenza A virus: Q. Tu, et al.; J. Virol.
70, 4246 (1996),
Abstract;
